Glutamate Carboxypeptidase II

"Glutamate Carboxypeptidase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.

Descriptor ID	D043425
MeSH Number(s)	D08.811.277.656.350.245.400 D08.811.277.656.350.555.500 D08.811.277.656.675.555.500
Concept/Terms	Glutamate Carboxypeptidase II Glutamate Carboxypeptidase II Carboxypeptidase II, Glutamate FOLH1 Protein N-Acetylaspartylglutamate Peptidase N Acetylaspartylglutamate Peptidase Peptidase, N-Acetylaspartylglutamate NAALADase L NAAG Peptidase NAALADase NAALADase II Folate Hydrolase I Hydrolase I, Folate N-Acetylated-alpha-Linked Acidic Dipeptidase Acidic Dipeptidase, N-Acetylated-alpha-Linked Dipeptidase, N-Acetylated-alpha-Linked Acidic N Acetylated alpha Linked Acidic Dipeptidase

Below are MeSH descriptors whose meaning is more general than "Glutamate Carboxypeptidase II".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Exopeptidases [D08.811.277.656.350]
Carboxypeptidases [D08.811.277.656.350.245]
Glutamate Carboxypeptidase II [D08.811.277.656.350.245.400]
Metalloexopeptidases [D08.811.277.656.350.555]
Glutamate Carboxypeptidase II [D08.811.277.656.350.555.500]
Metalloproteases [D08.811.277.656.675]
Metalloexopeptidases [D08.811.277.656.675.555]
Glutamate Carboxypeptidase II [D08.811.277.656.675.555.500]

Below are MeSH descriptors whose meaning is more specific than "Glutamate Carboxypeptidase II".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glutamate Carboxypeptidase II" by people in this website by year, and whether "Glutamate Carboxypeptidase II" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1999	0	1	1
2003	1	0	1
2011	0	1	1
2016	1	0	1
2024	1	0	1

Below are the most recent publications written about "Glutamate Carboxypeptidase II" by people in Profiles.

Trinh K, Chow DZ, Park H, Habib U, Offit L, Franquet E, Almeida RR, Wang Y, Borges N, Jamal F, Jacene HA, Heidari P, Ng TSC. Evaluating the Added Value of Concurrent Contrast-enhanced Diagnostic CT for PSMA-PET/CT Interpretation. Acad Radiol. 2025 Jan; 32(1):275-286.

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Von Hoff DD, Mita MM, Ramanathan RK, Weiss GJ, Mita AC, LoRusso PM, Burris HA, Hart LL, Low SC, Parsons DM, Zale SE, Summa JM, Youssoufian H, Sachdev JC. Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors. Clin Cancer Res. 2016 07 01; 22(13):3157-63.

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Vor?ckov? I, Ulbrich P, Diehl WE, Ruml T. Engineered retroviral virus-like particles for receptor targeting. Arch Virol. 2014 Apr; 159(4):677-88.

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Neale JH, Olszewski RT, Zuo D, Janczura KJ, Profaci CP, Lavin KM, Madore JC, Bzdega T. Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family. J Neurochem. 2011 Aug; 118(4):490-8.

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Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosom Med. 2011 Jun; 73(5):385-92.

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Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J, Smith CE, Ordovas JM, Li D, Lai CQ. Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. Public Health Nutr. 2011 Oct; 14(10):1805-12.

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Tsai G, Dunham KS, Drager U, Grier A, Anderson C, Collura J, Coyle JT. Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants. Synapse. 2003 Dec 15; 50(4):285-92.

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Speno HS, Luthi-Carter R, Macias WL, Valentine SL, Joshi AR, Coyle JT. Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II. Mol Pharmacol. 1999 Jan; 55(1):179-85.

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Sokoloff MH, Tso CL, Kaboo R, Nelson S, Ko J, Dorey F, Figlin RA, Pang S, deKernion J, Belldegrun A. Quantitative polymerase chain reaction does not improve preoperative prostate cancer staging: a clinicopathological molecular analysis of 121 patients. J Urol. 1996 Nov; 156(5):1560-6.

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Sokoloff MH, Tso CL, Kaboo R, Taneja S, Pang S, deKernion JB, Belldegrun AS. In vitro modulation of tumor progression-associated properties of hormone refractory prostate carcinoma cell lines by cytokines. Cancer. 1996 May 01; 77(9):1862-72.

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