Oncogene Protein p21(ras)
"Oncogene Protein p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D015689
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| MeSH Number(s) |
D08.811.277.040.330.300.400.500.300 D12.644.360.525.500.300 D12.776.157.325.515.500.300 D12.776.476.525.500.300 D12.776.624.664.520.750.710 D12.776.964.700.750.710 D12.776.964.775.750.710
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| Concept/Terms |
Oncogene Protein p21(ras)- Oncogene Protein p21(ras)
- p21 Transforming Viral Protein
- p21 v-H-ras
- p21 v H ras
- v-H-ras, p21
- p21(v-H-ras)
- p21 v-Ki-ras
- p21 v Ki ras
- v-Ki-ras, p21
- p21 v-ras
- p21 v ras
- v-ras, p21
- ras Oncogene p21 Product
- ras Oncogene Product p21
- p21 v-Ha-ras
- p21 v Ha ras
- v-Ha-ras, p21
- p21(v-Ha-ras)
- p21(v-K-ras)
- ras Oncogene Protein p21
- p21(v-Ki-ras)
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Below are MeSH descriptors whose meaning is more general than "Oncogene Protein p21(ras)".
Below are MeSH descriptors whose meaning is more specific than "Oncogene Protein p21(ras)".
This graph shows the total number of publications written about "Oncogene Protein p21(ras)" by people in this website by year, and whether "Oncogene Protein p21(ras)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Oncogene Protein p21(ras)" by people in Profiles.
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Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nat Aging. 2025 Jan; 5(1):21-27.
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Oberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K. TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. BMC Cancer. 2008 Jul 02; 8:189.
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Liu Y, Xiao H, Tian Y, Nekrasova T, Hao X, Lee HJ, Suh N, Yang CS, Minden A. The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer Res. 2008 Jul; 6(7):1215-24.
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Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007 Oct 25; 449(7165):1073-7.
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Benanti JA, Galloway DA. The normal response to RAS: senescence or transformation? Cell Cycle. 2004 Jun; 3(6):715-7.
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de la Serna IL, Roy K, Carlson KA, Imbalzano AN. MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes. J Biol Chem. 2001 Nov 02; 276(44):41486-91.
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Cheever MA, Disis ML, Bernhard H, Gralow JR, Hand SL, Huseby ES, Qin HL, Takahashi M, Chen W. Immunity to oncogenic proteins. Immunol Rev. 1995 Jun; 145:33-59.
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Edwards YJ, Perkins SJ. The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21. FEBS Lett. 1995 Jan 30; 358(3):283-6.
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Garlick DS, Sukumar S, Barbacid M, Petit D, Hamer PJ, Leav I, Lavecchio JA, Trimpe KL, Carney WP. Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas. Hybridoma. 1991 Feb; 10(1):95-102.