"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
|
| MeSH Number(s) |
D12.776.947.500
|
| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 4 | 6 | 10 |
| 2003 | 1 | 4 | 5 |
| 2004 | 4 | 1 | 5 |
| 2005 | 3 | 3 | 6 |
| 2006 | 1 | 6 | 7 |
| 2007 | 5 | 4 | 9 |
| 2008 | 2 | 3 | 5 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 3 | 4 |
| 2011 | 1 | 5 | 6 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 6 | 8 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 3 | 4 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 0 | 2 |
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click here.
Below are the most recent publications written about "Ubiquitin" by people in Profiles.
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Padhy AA, Mavor D, Sahoo S, Bolon DNA, Mishra P. Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection. Cell Rep. 2023 09 26; 42(9):113064.
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Arsenault HE, Benanti JA. Identification of Deubiquitinase Substrates in Saccharomyces cerevisiae by Systematic Overexpression. Methods Mol Biol. 2023; 2591:237-253.
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Wang Y, Punzo C, Ash JD, Lobanova ES. Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2118479119.
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Shen JL, Fortier TM, Wang R, Baehrecke EH. Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway. J Cell Biol. 2021 11 01; 220(11).
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Hepowit NL, Kolbe CC, Zelle SR, Latz E, MacGurn JA. Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation. FEBS J. 2022 08; 289(16):4797-4810.
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Wu PH, Zamore PD. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Mol Cell. 2021 01 21; 81(2):223-225.
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Desai PB, Stuck MW, Lv B, Pazour GJ. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020 07 06; 219(7).
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Mapa CE, Arsenault HE, Conti MM, Poti KE, Benanti JA. A balance of deubiquitinating enzymes controls cell cycle entry. Mol Biol Cell. 2018 11 15; 29(23):2821-2834.
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Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. 2018 11; 32(11):2339-2351.
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Biswas S, Willis LG, Fang M, Nie Y, Theilmann DA. Autographa californica Nucleopolyhedrovirus AC141 (Exon0), a Potential E3 Ubiquitin Ligase, Interacts with Viral Ubiquitin and AC66 To Facilitate Nucleocapsid Egress. J Virol. 2018 02 01; 92(3).