Excitatory Amino Acid Antagonists

"Excitatory Amino Acid Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

Descriptor ID	D018691
MeSH Number(s)	D27.505.519.625.190.300 D27.505.696.577.190.300
Concept/Terms	Excitatory Amino Acid Antagonists Excitatory Amino Acid Antagonists Antagonists, Excitatory Amino Acid Amino Acids, Excitatory, Antagonists Glutamate Receptor Antagonists Antagonists, Glutamate Receptor Receptor Antagonists, Glutamate EAA Antagonists Antagonists, EAA Glutamate Antagonists Antagonists, Glutamate Amino Acid Antagonists, Excitatory

Below are MeSH descriptors whose meaning is more general than "Excitatory Amino Acid Antagonists".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Neurotransmitter Agents [D27.505.519.625]
Excitatory Amino Acid Agents [D27.505.519.625.190]
Excitatory Amino Acid Antagonists [D27.505.519.625.190.300]
Physiological Effects of Drugs [D27.505.696]
Neurotransmitter Agents [D27.505.696.577]
Excitatory Amino Acid Agents [D27.505.696.577.190]
Excitatory Amino Acid Antagonists [D27.505.696.577.190.300]

Below are MeSH descriptors whose meaning is related to "Excitatory Amino Acid Antagonists".

Below are MeSH descriptors whose meaning is more specific than "Excitatory Amino Acid Antagonists".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Excitatory Amino Acid Antagonists" by people in this website by year, and whether "Excitatory Amino Acid Antagonists" was a major or minor topic of these publications.

Bar chart showing 34 publications over 17 distinct years, with a maximum of 4 publications in 2004 and 2011 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2001	0	1	1
2002	0	3	3
2004	0	4	4
2005	0	1	1
2006	0	2	2
2007	1	2	3
2008	1	0	1
2009	0	2	2
2010	1	1	2
2011	2	2	4
2013	2	2	4
2015	0	1	1
2016	0	1	1
2019	0	2	2
2025	1	0	1

Below are the most recent publications written about "Excitatory Amino Acid Antagonists" by people in Profiles.

Chen BK, Hunsberger HC, Whye A, Matthews LC, Yook A, Willner MJ, Logan RW, Johns S, Weisblum E, Denny CA. Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2025 Jul 15; 17(1):160.

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Joffe ME, Santiago CI, Oliver KH, Maksymetz J, Harris NA, Engers JL, Lindsley CW, Winder DG, Conn PJ. mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects. Neuron. 2020 01 08; 105(1):46-59.e3.

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Snyder AE, Salimando GJ, Winder DG, Silberman Y. Chronic Intermittent Ethanol and Acute Stress Similarly Modulate BNST CRF Neuron Activity via Noradrenergic Signaling. Alcohol Clin Exp Res. 2019 08; 43(8):1695-1701.

View in: PubMed
Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG. Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. Neuropsychopharmacology. 2016 07; 41(8):2062-71.

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Haj-Mirzaian A, Kordjazy N, Haj-Mirzaian A, Ostadhadi S, Ghasemi M, Amiri S, Faizi M, Dehpour A. Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests. Psychopharmacology (Berl). 2015 Oct; 232(19):3551-61.

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Ghasemi M, Phillips C, Trillo L, De Miguel Z, Das D, Salehi A. The role of NMDA receptors in the pathophysiology and treatment of mood disorders. Neurosci Biobehav Rev. 2014 Nov; 47:336-58.

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Ghasemi M, Kazemi MH, Yoosefi A, Ghasemi A, Paragomi P, Amini H, Afzali MH. Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder. Psychiatry Res. 2014 Feb 28; 215(2):355-61.

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Louderback KM, Wills TA, Muglia LJ, Winder DG. Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia. Transl Psychiatry. 2013 Dec 03; 3:e331.

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Yosipovitch G, Bernhard JD. Clinical practice. Chronic pruritus. N Engl J Med. 2013 Apr 25; 368(17):1625-34.

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Dysken MW, Guarino PD, Vertrees JE, Asthana S, Sano M, Llorente M, Pallaki M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Carney S, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, Kowall NW, Chopra MP, Craft S, Thielke S, Turvey CL, Woodman C, Monnell KA, Gordon K, Tomaska J, Vatassery G. Vitamin E and memantine in Alzheimer's disease: clinical trial methods and baseline data. Alzheimers Dement. 2014 Jan; 10(1):36-44.

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