"Metallothionein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
| Descriptor ID |
D008668
|
| MeSH Number(s) |
D12.776.556.670
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Metallothionein".
Below are MeSH descriptors whose meaning is more specific than "Metallothionein".
This graph shows the total number of publications written about "Metallothionein" by people in this website by year, and whether "Metallothionein" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metallothionein" by people in Profiles.
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Verdejo-Torres O, Klein DC, Novoa-Aponte L, Carrazco-Carrillo J, Bonilla-Pinto D, Rivera A, Bakhshian A, Fitisemanu FM, Jim?nez-Gonz?lez ML, Flinn L, Pezacki AT, Lanzirotti A, Ortiz Frade LA, Chang CJ, Navea JG, Blaby-Haas CE, Hainer SJ, Padilla-Benavides T. Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis. PLoS Genet. 2024 Dec; 20(12):e1011495.
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Cavalca E, Cesani M, Gifford JC, Sena-Esteves M, Terreni MR, Leoncini G, Peviani M, Biffi A. Metallothioneins are neuroprotective agents in lysosomal storage disorders. Ann Neurol. 2018 02; 83(2):418-432.
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Shuja RN, Taimuri SU, Shakoori FR, Shakoori AR. Efficient expression of truncated recombinant cadmium-metallothionein gene of a ciliate, Tetrahymena tropicalis lahorensis in Escherichia coli. Mol Biol Rep. 2013 Dec; 40(12):7061-8.
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Dar S, Shuja RN, Shakoori AR. A synthetic cadmium metallothionein gene (PMCd1syn) of Paramecium species: expression, purification and characteristics of metallothionein protein. Mol Biol Rep. 2013 Feb; 40(2):983-97.
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Suleman A, Shakoori AR. Evaluation of physiological importance of metallothionein protein expressed by Tetrahymena cadmium metallothionein 1 (TMCd1) gene in Escherichia coli. J Cell Biochem. 2012 May; 113(5):1616-22.
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Hyldahl RD, O'Fallon KS, Schwartz LM, Clarkson PM. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. J Appl Physiol (1985). 2010 Nov; 109(5):1515-23.
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Chaudhry R, Shakoori AR. Isolation and characterization of a novel copper-inducible metallothionein gene of a ciliate, Tetrahymena tropicalis lahorensis. J Cell Biochem. 2010 Jun 01; 110(3):630-44.
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Shuja RN, Shakoori AR. Identification and cloning of first cadmium metallothionein like gene from locally isolated ciliate, Paramecium sp. Mol Biol Rep. 2009 Mar; 36(3):549-60.
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Shuja RN, Shakoori AR. Identification, cloning and sequencing of a novel stress inducible metallothionein gene from locally isolated Tetrahymena tropicalis lahorensis. Gene. 2007 Dec 15; 405(1-2):19-26.
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von Gall C, Weaver DR. Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus. Neurobiol Aging. 2008 Mar; 29(3):464-70.