Wiskott-Aldrich Syndrome Protein Family
"Wiskott-Aldrich Syndrome Protein Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of microfilament proteins whose name derives from the fact that mutations in members of this protein family have been associated with WISKOTT-ALDRICH SYNDROME. They are involved in ACTIN polymerization and contain a polyproline-rich region that binds to PROFILIN, and a verprolin homology domain that binds G-ACTIN.
| Descriptor ID |
D051300
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| MeSH Number(s) |
D05.750.078.730.912 D12.776.220.525.912
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Wiskott-Aldrich Syndrome Protein Family".
Below are MeSH descriptors whose meaning is more specific than "Wiskott-Aldrich Syndrome Protein Family".
This graph shows the total number of publications written about "Wiskott-Aldrich Syndrome Protein Family" by people in this website by year, and whether "Wiskott-Aldrich Syndrome Protein Family" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Wiskott-Aldrich Syndrome Protein Family" by people in Profiles.
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Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, Skehan BM, Umetani J, Brautigam CA, Leong JM, Rosen MK. Hierarchical regulation of WASP/WAVE proteins. Mol Cell. 2008 Nov 07; 32(3):426-38.
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Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10; 281(6):3513-20.
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Bannigan A, Baskin TI. Directional cell expansion--turning toward actin. Curr Opin Plant Biol. 2005 Dec; 8(6):619-24.