Filamins

"Filamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.

Descriptor ID	D064448
MeSH Number(s)	A11.284.430.214.190.750.050.414 D05.750.078.730.315 D12.776.210.249 D12.776.220.525.315
Concept/Terms	Filamins Filamins Filamin Filamin B Filamin B beta-Filamin beta Filamin beta-Filamins Filamin 1-Like Protein 1-Like Protein, Filamin 1-Like Proteins, Filamin Filamin 1 Like Protein Filamin 1-Like Proteins Protein, Filamin 1-Like Proteins, Filamin 1-Like Merofilamins Merofilamins Merofilamin Filamin A Filamin A Filamin 1 alpha-Filamin alpha Filamin alpha-Filamins 280 kDa Actin-Binding Protein 280 kDa Actin Binding Protein Filamin C Filamin C Cs, Filamin Filamin Cs

Below are MeSH descriptors whose meaning is more general than "Filamins".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Intracellular Space [A11.284.430]
Cytoplasm [A11.284.430.214]
Cytoplasmic Structures [A11.284.430.214.190]
Cytoskeleton [A11.284.430.214.190.750]
Actin Cytoskeleton [A11.284.430.214.190.750.050]
Filamins [A11.284.430.214.190.750.050.414]
Chemicals and Drugs [D]
Macromolecular Substances [D05]
Polymers [D05.750]
Biopolymers [D05.750.078]
Microfilament Proteins [D05.750.078.730]
Filamins [D05.750.078.730.315]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Filamins [D12.776.210.249]
Cytoskeletal Proteins [D12.776.220]
Microfilament Proteins [D12.776.220.525]
Filamins [D12.776.220.525.315]

Below are MeSH descriptors whose meaning is more specific than "Filamins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Filamins" by people in this website by year, and whether "Filamins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2006 and 2007 and 2011 and 2012 and 2017 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2007	0	1	1
2011	0	1	1
2012	0	1	1
2017	1	0	1
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "Filamins" by people in Profiles.

K?lbel H, Roos A, van der Ven PFM, Evangelista T, Nolte K, Johnson K, T?pf A, Wilson M, Kress W, Sickmann A, Straub V, Kollipara L, Weis J, F?rst DO, Schara U. First clinical and myopathological description of a myofibrillar myopathy with congenital onset and homozygous mutation in FLNC. Hum Mutat. 2020 09; 41(9):1600-1614.

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Kremer TM, Lindsay ME, Kinane TB, Hawley MH, Little BP, Mino-Kenudson M. Case 28-2019: A 22-Year-Old Woman with Dyspnea and Chest Pain. N Engl J Med. 2019 09 12; 381(11):1059-1067.

View in: PubMed
Tucker NR, McLellan MA, Hu D, Ye J, Parsons VA, Mills RW, Clauss S, Dolmatova E, Shea MA, Milan DJ, Scott NS, Lindsay M, Lubitz SA, Domian IJ, Stone JR, Lin H, Ellinor PT. Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Circ Cardiovasc Genet. 2017 Dec; 10(6).

View in: PubMed
Clapham KR, Yu TW, Ganesh VS, Barry B, Chan Y, Mei D, Parrini E, Funalot B, Dupuis L, Nezarati MM, du Souich C, van Karnebeek C, Guerrini R, Walsh CA. FLNA genomic rearrangements cause periventricular nodular heterotopia. Neurology. 2012 Jan 24; 78(4):269-78.

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Duff RM, Tay V, Hackman P, Ravenscroft G, McLean C, Kennedy P, Steinbach A, Sch?ffler W, van der Ven PFM, F?rst DO, Song J, Djinovic-Carugo K, Penttil? S, Raheem O, Reardon K, Malandrini A, Gambelli S, Villanova M, Nowak KJ, Williams DR, Landers JE, Brown RH, Udd B, Laing NG. Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy. Am J Hum Genet. 2011 Jun 10; 88(6):729-740.

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Annibali V, Di Giovanni S, Cannoni S, Giugni E, Bomprezzi R, Mattei C, Elkahloun A, Coccia EM, Alf? M, Orzi F, Ristori G, Salvetti M. Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis. Autoimmunity. 2007 Feb; 40(1):16-22.

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Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes. 2006 Jun; 55(6):1776-82.

View in: PubMed

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