Tight Junctions

"Tight Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

Descriptor ID	D019108
MeSH Number(s)	A11.284.149.165.420.820
Concept/Terms	Tight Junctions Tight Junctions Junction, Tight Junctions, Tight Tight Junction Zonula Occludens Occluden, Zonula Occludens, Zonula Zonula Occluden Occluding Junctions Junction, Occluding Junctions, Occluding Occluding Junction

Below are MeSH descriptors whose meaning is more general than "Tight Junctions".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Intercellular Junctions [A11.284.149.165.420]
Tight Junctions [A11.284.149.165.420.820]

Below are MeSH descriptors whose meaning is related to "Tight Junctions".

Below are MeSH descriptors whose meaning is more specific than "Tight Junctions".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tight Junctions" by people in this website by year, and whether "Tight Junctions" was a major or minor topic of these publications.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 3 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	0	1	1
2004	1	0	1
2006	0	1	1
2007	1	2	3
2010	1	0	1
2011	1	1	2
2012	1	0	1
2016	1	0	1
2017	1	1	2
2024	0	1	1

Below are the most recent publications written about "Tight Junctions" by people in Profiles.

Hara T, Asatsu M, Yamagishi T, Ohata C, Funatsu H, Takahashi Y, Shirai M, Nakata C, Katayama H, Kaji T, Fujie T, Yamamoto C. Cadmium Induces Vascular Endothelial Cell Detachment by Downregulating Claudin-5 and ZO-1 Levels. Int J Mol Sci. 2024 Oct 14; 25(20).

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Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA. Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation. Gut Microbes. 2017 11 02; 8(6):544-560.

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Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B. Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):E3344-E3353.

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Roy J, Kim B, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S. Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016 Feb 12; 7:10666.

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Wu WC, Liu CH, Wang NK, Chen KJ, Chen TL, Hwang YS, Liao PJ, Li LM, Lai CC. Lens subluxation after plasmin and SF6 injections in rabbit eyes. PLoS One. 2014; 9(11):e112957.

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Nagaoka K, Udagawa T, Richter JD. CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity. Nat Commun. 2012 Feb 14; 3:675.

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Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 01; 361(1):68-78.

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Paramasivam M, Sarkeshik A, Yates JR, Fernandes MJ, McCollum D. Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. Mol Biol Cell. 2011 Oct; 22(19):3725-33.

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Larre I, Lazaro A, Contreras RG, Balda MS, Matter K, Flores-Maldonado C, Ponce A, Flores-Benitez D, Rincon-Heredia R, Padilla-Benavides T, Castillo A, Shoshani L, Cereijido M. Ouabain modulates epithelial cell tight junction. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11387-92.

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Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G599-609.

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