Limit of Detection

"Limit of Detection" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.

Descriptor ID	D057230
MeSH Number(s)	E05.318.740.872.374 N05.715.360.750.725.500 N06.850.520.830.872.500
Concept/Terms	Limit of Detection Limit of Detection Detection Limit Detection Limits Limits of Detection

Below are MeSH descriptors whose meaning is more general than "Limit of Detection".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Epidemiologic Methods [E05.318]
Statistics as Topic [E05.318.740]
Sensitivity and Specificity [E05.318.740.872]
Limit of Detection [E05.318.740.872.374]
Health Care [N]
Health Care Quality, Access, and Evaluation [N05]
Quality of Health Care [N05.715]
Health Care Evaluation Mechanisms [N05.715.360]
Statistics as Topic [N05.715.360.750]
Sensitivity and Specificity [N05.715.360.750.725]
Limit of Detection [N05.715.360.750.725.500]
Environment and Public Health [N06]
Public Health [N06.850]
Epidemiologic Methods [N06.850.520]
Statistics as Topic [N06.850.520.830]
Sensitivity and Specificity [N06.850.520.830.872]
Limit of Detection [N06.850.520.830.872.500]

Below are MeSH descriptors whose meaning is related to "Limit of Detection".

Below are MeSH descriptors whose meaning is more specific than "Limit of Detection".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Limit of Detection" by people in this website by year, and whether "Limit of Detection" was a major or minor topic of these publications.

Bar chart showing 40 publications over 16 distinct years, with a maximum of 6 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	2	3
2011	0	1	1
2012	0	2	2
2013	0	1	1
2014	0	1	1
2015	1	5	6
2016	0	3	3
2017	0	3	3
2018	0	5	5
2019	0	4	4
2020	0	3	3
2021	0	2	2
2023	0	1	1
2024	0	1	1
2025	0	3	3
2026	0	1	1

Below are the most recent publications written about "Limit of Detection" by people in Profiles.

Pfefferle S, N?rz D, Giersch K, Grunwald M, Tang HT, Pfl?ger LS, L?tgehetmann M. Refined fully automated RT-qPCR assay for simultaneous detection of SARS-CoV-2, Influenza A/B, and RSV with target optimization for improved variant resilience. J Clin Virol. 2026 Apr; 183:105924.

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Liu H, Zheng Z, Zhou C, Chen Z, Peng K, Li C, Huang H, Wang L, Liu Y, Li L, Xu S, Li Y, Yang Y, Xiang Y, Zheng J. Photoelectrochemical detection of epigenetic 5-hydroxymethylcytosine based on Cu2O@CuO@Ag and self-triggered isothermal amplification. Anal Chim Acta. 2026 Jan 22; 1384:344968.

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Giersch K, N?rz D, Grunwald M, Pfefferle S, Pfl?ger LS, Fischer N, Aepfelbacher M, L?tgehetmann M. Adaptation and validation of a gastrointestinal panel to detect diarrheal virus pathogens on a high-throughput qPCR system. Med Microbiol Immunol. 2025 Jun 03; 214(1):28.

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Anderson RK, Nugen SR. Genetic engineering of bacteriophage S16 for Salmonella separation, concentration, and detection. Anal Bioanal Chem. 2025 Jul; 417(18):4069-4081.

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Uljon S, Tolan NV, Mahowald GK, Khaliq T, Urwiller ED, Fernandes MD, Basu SS, Kang P, Erickson TB, Hayes BD, Chai PR, Melanson SEF. Performance of a Norfentanyl Immunoassay in Specimens with Low Concentrations of Fentanyl and/or Norfentanyl. J Appl Lab Med. 2024 Sep 03; 9(5):895-904.

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Alizadeh Sani M, Jahed-Khaniki G, Ehsani A, Shariatifar N, Dehghani MH, Hashemi M, Hosseini H, Abdollahi M, Hassani S, Bayrami Z, McClements DJ. Metal-Organic Framework Fluorescence Sensors for Rapid and Accurate Detection of Melamine in Milk Powder. Biosensors (Basel). 2023 Jan 06; 13(1).

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Mehmood T, Hanif S, Azhar F, Ali I, Alafnan A, Hussain T, Moin A, Alamri MA, Syed MA. HPLC Method Validation for the Estimation of Lignocaine HCl, Ketoprofen and Hydrocortisone: Greenness Analysis Using AGREE Score. Int J Mol Sci. 2022 Dec 27; 24(1).

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Raza A, Murtaza SH, Hanif S, Iqbal J, Ali I, Aftab T, Shakir R, Bedar R, Syed MA. Validation of a rapid and economical RP-HPLC method for simultaneous determination of metformin hydrochloride and sitagliptin phosphate monohydrate: Greenness evaluation using AGREE score. Pak J Pharm Sci. 2022 Jan; 35(1):15-21.

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Foppe KS, Kujawinski EB, Duvallet C, Endo N, Erickson TB, Chai PR, Matus M. Analysis of 39 drugs and metabolites, including 8 glucuronide conjugates, in an upstream wastewater network via HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jun 30; 1176:122747.

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N?rz D, Hoffmann A, Aepfelbacher M, Pfefferle S, L?tgehetmann M. Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform. J Med Microbiol. 2021 Feb; 70(2).

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