"alpha-Mannosidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
| Descriptor ID |
D043323
|
| MeSH Number(s) |
D08.811.277.450.625.500
|
| Concept/Terms |
alpha-Mannosidase- alpha-Mannosidase
- alpha Mannosidase
- alpha-D-Mannoside Mannohydrolase
- Mannohydrolase, alpha-D-Mannoside
- alpha D Mannoside Mannohydrolase
- Neutral alpha-Mannosidase
- Neutral alpha Mannosidase
- alpha-Mannosidase, Neutral
- alpha-D-Mannosidase
- alpha D Mannosidase
Lysosomal alpha-Mannosidase- Lysosomal alpha-Mannosidase
- Lysosomal alpha Mannosidase
- alpha-Mannosidase, Lysosomal
- LAMAN
- alpha Mannosidase B
- Mannosidase B, alpha
|
Below are MeSH descriptors whose meaning is more general than "alpha-Mannosidase".
Below are MeSH descriptors whose meaning is more specific than "alpha-Mannosidase".
This graph shows the total number of publications written about "alpha-Mannosidase" by people in this website by year, and whether "alpha-Mannosidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "alpha-Mannosidase" by people in Profiles.
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Verheijen J, Wong SY, Rowe JH, Raymond K, Stoddard J, Delmonte OM, Bosticardo M, Dobbs K, Niemela J, Calzoni E, Pai SY, Choi U, Yamazaki Y, Comeau AM, Janssen E, Henderson L, Hazen M, Berry G, Rosenzweig SD, Aldhekri HH, He M, Notarangelo LD, Morava E. Defining a new immune deficiency syndrome: MAN2B2-CDG. J Allergy Clin Immunol. 2020 03; 145(3):1008-1011.
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Cao J, Li Y, Xia W, Reddig K, Hu W, Xie W, Li HS, Han J. A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J. 2011 Jul 29; 30(18):3701-13.
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Magnelli P, Cipollo JF, Ratner DM, Cui J, Kelleher D, Gilmore R, Costello CE, Robbins PW, Samuelson J. Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica. J Biol Chem. 2008 Jun 27; 283(26):18355-64.
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Arcaro KF, Wang J, Otis CN, Zuckerman BM. Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures. Anticancer Res. 2004 Jan-Feb; 24(1):139-44.