Sick Sinus Syndrome

"Sick Sinus Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.

Descriptor ID	D012804
MeSH Number(s)	C14.280.067.093.249 C14.280.067.558.536 C14.280.123.500.536 C23.550.073.093.249 C23.550.073.425.440
Concept/Terms	Sick Sinus Syndrome Sick Sinus Syndrome Syndrome, Sick Sinus Sick Sinus Node Syndrome Sinus Node Dysfunction Sinus Node Dysfunction Dysfunction, Sinus Node Dysfunctions, Sinus Node Sinus Node Disease Sinus Node Diseases

Below are MeSH descriptors whose meaning is more general than "Sick Sinus Syndrome".

Diseases [C]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Arrhythmias, Cardiac [C14.280.067]
Arrhythmia, Sinus [C14.280.067.093]
Sick Sinus Syndrome [C14.280.067.093.249]
Heart Block [C14.280.067.558]
Sick Sinus Syndrome [C14.280.067.558.536]
Cardiac Conduction System Disease [C14.280.123]
Heart Block [C14.280.123.500]
Sick Sinus Syndrome [C14.280.123.500.536]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Arrhythmias, Cardiac [C23.550.073]
Arrhythmia, Sinus [C23.550.073.093]
Sick Sinus Syndrome [C23.550.073.093.249]
Heart Block [C23.550.073.425]
Sick Sinus Syndrome [C23.550.073.425.440]

Below are MeSH descriptors whose meaning is related to "Sick Sinus Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Sick Sinus Syndrome".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sick Sinus Syndrome" by people in this website by year, and whether "Sick Sinus Syndrome" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2011	2	0	2
2022	0	1	1
2025	0	1	1

Below are the most recent publications written about "Sick Sinus Syndrome" by people in Profiles.

Weng LC, R?m? JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, Morrill VN, Wang X, Nauffal V, Sun YV, Beer D, Lee S, Nadkarni GN, Duong T, Wang B, Czuba T, Austin TR, Yoneda ZT, Friedman DJ, Clayton A, Hyman MC, Judy RL, Skanes AC, Orland KM, Treu TM, Oetjens MT, Alonso A, Soliman EZ, Lin H, Lunetta KL, van der Pals J, Issa TZ, Nafissi NA, May HT, Leong-Sit P, Roselli C, Choi SH, Khan HR, Knight S, Karlsson Linn?r R, Bezzina CR, Ripatti S, Heckbert SR, Gaziano JM, Loos RJF, Psaty BM, Smith JG, Benjamin EJ, Arking DE, Rader DJ, Shah SH, Roden DM, Damrauer SM, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Haggerty CM, Cho K, Palotie A, Wilson PWF, Ellinor PT, Lubitz SA. The impact of common and rare genetic variants on bradyarrhythmia development. Nat Genet. 2025 Jan; 57(1):53-64.

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Morishima I, Kanzaki Y, Morita Y, Inoue K, Kobori A, Kaitani K, Kurotobi T, Yamaji H, Matsui Y, Nakazawa Y, Kusano K, Tomomatsu T, Ikai Y, Furui K, Yamauchi R, Miyazawa H, Tanaka N, Morimoto T, Kimura T, Shizuta S. Catheter Ablation for Paroxysmal Atrial Fibrillation With Sick Sinus Syndrome: Insights From the Kansai Plus Atrial Fibrillation Registry. Heart Lung Circ. 2023 Feb; 32(2):205-214.

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Elkayam LU, Koehler JL, Sheldon TJ, Glotzer TV, Rosenthal LS, Lamas GA. The influence of atrial and ventricular pacing on the incidence of atrial fibrillation: a meta-analysis. Pacing Clin Electrophysiol. 2011 Dec; 34(12):1593-9.

View in: PubMed
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011 Aug; 121(8):3277-88.

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Meyer TE, Casadei B, Aurigemma GP, Gaasch WH. Which indexes of filling behavior should be used to characterize left ventricular diastolic function when changes in heart rate and atrioventricular delay occur? J Am Soc Echocardiogr. 1997 Sep; 10(7):689-98.

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Spodick DH. Pericarditis and the sick sinus syndrome. Arch Intern Med. 1985 Oct; 145(10):1930.

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Spodick DH. Arrhythmias and sinus node dysfunction. JAMA. 1984 May 18; 251(19):2513-4.

View in: PubMed

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