Glycine Dehydrogenase (Decarboxylating)
"Glycine Dehydrogenase (Decarboxylating)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PYRIDOXAL PHOSPHATE dependent enzyme that catalyzes the decarboxylation of GLYCINE with the transfer of an aminomethyl group to the LIPOIC ACID moiety of the GLYCINE DECARBOXYLASE COMPLEX H-PROTEIN. Defects in P-protein are the cause of non-ketotic hyperglycinemia. It is one of four subunits of the glycine decarboxylase complex.
| Descriptor ID |
D050841
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| MeSH Number(s) |
D05.500.562.452.200 D08.811.600.391.200 D08.811.682.664.500.498.500
|
| Concept/Terms |
Glycine Dehydrogenase (Decarboxylating)- Glycine Dehydrogenase (Decarboxylating)
- P-protein, Glycine Decarboxylase
- Decarboxylase P-protein, Glycine
- Glycine Decarboxylase P-protein
- P protein, Glycine Decarboxylase
- Glycine Decarboxylase Complex P-Protein
- Glycine Decarboxylase Complex P Protein
- Glycine Cleavage System P-Protein
- Glycine Cleavage System P Protein
- Glycine Decarboxylase
- Decarboxylase, Glycine
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Below are MeSH descriptors whose meaning is more general than "Glycine Dehydrogenase (Decarboxylating)".
Below are MeSH descriptors whose meaning is more specific than "Glycine Dehydrogenase (Decarboxylating)".
This graph shows the total number of publications written about "Glycine Dehydrogenase (Decarboxylating)" by people in this website by year, and whether "Glycine Dehydrogenase (Decarboxylating)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glycine Dehydrogenase (Decarboxylating)" by people in Profiles.
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Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16; 520(7547):363-7.
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Narisawa A, Komatsuzaki S, Kikuchi A, Niihori T, Aoki Y, Fujiwara K, Tanemura M, Hata A, Suzuki Y, Relton CL, Grinham J, Leung KY, Partridge D, Robinson A, Stone V, Gustavsson P, Stanier P, Copp AJ, Greene ND, Tominaga T, Matsubara Y, Kure S. Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet. 2012 Apr 01; 21(7):1496-503.