Receptor-Interacting Protein Serine-Threonine Kinase 2

"Receptor-Interacting Protein Serine-Threonine Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A RIP serine-theonine kinase that contains a C-terminal caspase activation and recruitment domain. It can signal by associating with other CARD-signaling adaptor proteins and INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.

Descriptor ID	D053475
MeSH Number(s)	D08.811.913.696.620.682.700.801.500 D12.644.360.024.131.750 D12.644.360.024.500.186.500 D12.644.360.075.358.750 D12.776.157.057.006.750 D12.776.157.057.500.186.500 D12.776.476.024.139.750 D12.776.476.024.500.186.500 D12.776.476.075.358.750
Concept/Terms	Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptor Interacting Protein Serine Threonine Kinase 2 CARDIAK Receptor-Interacting Serine-Threonine Kinase 2 Receptor Interacting Serine Threonine Kinase 2 RIPK2 Protein RICK Protein CARD-containing Interleukin (IL)-1 beta Converting Enzyme

Below are MeSH descriptors whose meaning is more general than "Receptor-Interacting Protein Serine-Threonine Kinase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D08.811.913.696.620.682.700.801.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
CARD Signaling Adaptor Proteins [D12.644.360.024.131]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.644.360.024.131.750]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.644.360.024.500.186]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.644.360.024.500.186.500]
Apoptosis Regulatory Proteins [D12.644.360.075]
CARD Signaling Adaptor Proteins [D12.644.360.075.358]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.644.360.075.358.750]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
CARD Signaling Adaptor Proteins [D12.776.157.057.006]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.157.057.006.750]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.157.057.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.500.186]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.157.057.500.186.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
CARD Signaling Adaptor Proteins [D12.776.476.024.139]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.476.024.139.750]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.476.024.500]
Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.500.186]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.476.024.500.186.500]
Apoptosis Regulatory Proteins [D12.776.476.075]
CARD Signaling Adaptor Proteins [D12.776.476.075.358]
Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.476.075.358.750]

Below are MeSH descriptors whose meaning is related to "Receptor-Interacting Protein Serine-Threonine Kinase 2".

Below are MeSH descriptors whose meaning is more specific than "Receptor-Interacting Protein Serine-Threonine Kinase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor-Interacting Protein Serine-Threonine Kinase 2" by people in this website by year, and whether "Receptor-Interacting Protein Serine-Threonine Kinase 2" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	2	2
2009	0	1	1
2015	1	0	1
2018	1	0	1
2022	0	1	1

Below are the most recent publications written about "Receptor-Interacting Protein Serine-Threonine Kinase 2" by people in Profiles.

Jurynec MJ, Gavile CM, Honeggar M, Ma Y, Veerabhadraiah SR, Novak KA, Hoshijima K, Kazmers NH, Grunwald DJ. NOD/RIPK2 signalling pathway contributes to osteoarthritis susceptibility. Ann Rheum Dis. 2022 10; 81(10):1465-1473.

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Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ. A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis. Hum Mol Genet. 2018 07 01; 27(13):2383-2391.

View in: PubMed
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug; 11(8):611-7.

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Yang Z, Grinchuk V, Smith A, Qin B, Bohl JA, Sun R, Notari L, Zhang Z, Sesaki H, Urban JF, Shea-Donohue T, Zhao A. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infect Immun. 2013 Jun; 81(6):1905-14.

View in: PubMed
Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM, Kelliher MA. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog. 2009 Jul; 5(7):e1000500.

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Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem. 2007 Dec 14; 282(50):36223-9.

View in: PubMed
Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC. Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol Cell Biol. 2007 Sep; 27(17):6012-25.

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Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb; 8(2):198-205.

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