CRADD Signaling Adaptor Protein
"CRADD Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2.
| Descriptor ID |
D053420
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| MeSH Number(s) |
D12.644.360.024.131.186 D12.644.360.024.285.050 D12.644.360.024.500.050 D12.644.360.075.358.186 D12.644.360.075.421.050 D12.776.157.057.006.186 D12.776.157.057.018.050 D12.776.157.057.500.050 D12.776.476.024.139.186 D12.776.476.024.320.050 D12.776.476.024.500.050 D12.776.476.075.358.186 D12.776.476.075.421.050
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| Concept/Terms |
CRADD Signaling Adaptor Protein- CRADD Signaling Adaptor Protein
- RIP-Associated Protein With a Death Domain
- RIP Associated Protein With a Death Domain
- RAIDD Signaling Adaptor Protein
- Caspase and Rip Adaptor with Death Domain Protein
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Below are MeSH descriptors whose meaning is more general than "CRADD Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "CRADD Signaling Adaptor Protein".
This graph shows the total number of publications written about "CRADD Signaling Adaptor Protein" by people in this website by year, and whether "CRADD Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "CRADD Signaling Adaptor Protein" by people in Profiles.
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Di Donato N, Jean YY, Maga AM, Krewson BD, Shupp AB, Avrutsky MI, Roy A, Collins S, Olds C, Willert RA, Czaja AM, Johnson R, Stover JA, Gottlieb S, Bartholdi D, Rauch A, Goldstein A, Boyd-Kyle V, Aldinger KA, Mirzaa GM, Nissen A, Brigatti KW, Puffenberger EG, Millen KJ, Strauss KA, Dobyns WB, Troy CM, Jinks RN. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet. 2016 Nov 03; 99(5):1117-1129.
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Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA. Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012; 7(1):e28936.