CASP8 and FADD-Like Apoptosis Regulating Protein
"CASP8 and FADD-Like Apoptosis Regulating Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
| Descriptor ID |
D053446
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| MeSH Number(s) |
D12.644.360.024.285.024 D12.644.360.024.500.024 D12.644.360.075.421.024 D12.776.157.057.018.024 D12.776.476.075.421.024
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "CASP8 and FADD-Like Apoptosis Regulating Protein".
Below are MeSH descriptors whose meaning is more specific than "CASP8 and FADD-Like Apoptosis Regulating Protein".
This graph shows the total number of publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in this website by year, and whether "CASP8 and FADD-Like Apoptosis Regulating Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
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Below are the most recent publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in Profiles.
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Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature. 2011 Mar 17; 471(7338):373-6.
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Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. Gastroenterology. 2009 Sep; 137(3):934-44, 944.e1-4.
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Yu JG, Sewright K, Hubal MJ, Liu JX, Schwartz LM, Hoffman EP, Clarkson PM. Investigation of gene expression in C(2)C(12) myotubes following simvastatin application and mechanical strain. J Atheroscler Thromb. 2009 Mar; 16(1):21-9.
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Hinshaw-Makepeace J, Huston G, Fortner KA, Russell JQ, Holoch D, Swain S, Budd RC. c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival. Eur J Immunol. 2008 Jan; 38(1):54-63.
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Li H, Cai X, Fan X, Moquin B, Stoicov C, Houghton J. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G263-75.
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Misra RS, Jelley-Gibbs DM, Russell JQ, Huston G, Swain SL, Budd RC. Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates. J Immunol. 2005 Apr 01; 174(7):3999-4009.
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Ramp U, Caliskan E, Mahotka C, Krieg A, Heikaus S, Gabbert HE, Gerharz CD. Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer. 2003 Jun 02; 88(11):1800-7.