Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Campbell WA, Yang H, Zetterberg H, Baulac S, Sears JA, Liu T, Wong ST, Zhong TP, Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006 Mar; 96(5):1423-40.
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Alzheimer Disease
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Animals
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Animals, Genetically Modified
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Apoptosis
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Blotting, Northern
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Blotting, Western
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Body Patterning
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Cell Count
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Embryo, Nonmammalian
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Fish Proteins
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Gene Expression Regulation, Developmental
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Immunohistochemistry
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In Situ Hybridization
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In Situ Nick-End Labeling
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Indoles
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Membrane Proteins
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Neurons
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Oligonucleotides, Antisense
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Presenilin-2
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Receptors, Notch
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger
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Tumor Suppressor Protein p53
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Zebrafish
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Zebrafish Proteins