Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Tothova Z, Valton AL, Gorelov RA, Vallurupalli M, Krill-Burger JM, Holmes A, Landers CC, Haydu JE, Malolepsza E, Hartigan C, Donahue M, Popova KD, Koochaki S, Venev SV, Rivera J, Chen E, Lage K, Schenone M, D'Andrea AD, Carr SA, Morgan EA, Dekker J, Ebert BL. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. JCI Insight. 2021 02 08; 6(3).
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Animals
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Cell Cycle Proteins
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Cell Line, Tumor
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Chromatin
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Chromosomal Proteins, Non-Histone
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Disease Models, Animal
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DNA Damage
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DNA Repair
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Female
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Humans
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K562 Cells
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Leukemia, Myeloid, Acute
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred NOD
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Mice, Mutant Strains
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Mice, SCID
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Mice, Transgenic
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Mutation
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Myelodysplastic Syndromes
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Nuclear Proteins
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Phthalazines
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Poly(ADP-ribose) Polymerase Inhibitors
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U937 Cells
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Xenograft Model Antitumor Assays