Retinoic Acid 4-Hydroxylase
"Retinoic Acid 4-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytochrome P450 enzyme that resides in the ENDOPLASMIC RETICULUM. It catalyzes the conversion of trans-RETINOIC ACID to 4-hydroxyretinoic acid.
| Descriptor ID |
D000072516
|
| MeSH Number(s) |
D08.244.453.498.500 D08.811.682.690.708.170.485.500 D12.776.422.220.453.498.500
|
| Concept/Terms |
Retinoic Acid 4-Hydroxylase- Retinoic Acid 4-Hydroxylase
- Retinoic Acid 4 Hydroxylase
- P450RAI
- Cytochrome P450 4-Hydroxylase
- Cytochrome P450 4 Hydroxylase
- CYP450 4-Hydroxylase
- RA-4-Hydroxylase
- RA 4 Hydroxylase
Cytochrome P-450 CYP26B1- Cytochrome P-450 CYP26B1
- CYP26B1, Cytochrome P-450
- Cytochrome P 450 CYP26B1
- Retinoic Acid-Metabolizing Enzyme, CYP26B1
- Retinoic Acid Metabolizing Enzyme, CYP26B1
- CYP26B1
- Cytochrome P-450 26B1
|
Below are MeSH descriptors whose meaning is more general than "Retinoic Acid 4-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Retinoic Acid 4-Hydroxylase".
This graph shows the total number of publications written about "Retinoic Acid 4-Hydroxylase" by people in this website by year, and whether "Retinoic Acid 4-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Retinoic Acid 4-Hydroxylase" by people in Profiles.
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Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa JL, Gerber JM, Jones RJ. Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16121-6.
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Topletz AR, Le HN, Lee N, Chapman JD, Kelly EJ, Wang J, Isoherranen N. Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy. Drug Metab Dispos. 2013 Feb; 41(2):312-9.
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Lee LM, Leung CY, Tang WW, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS, Shum AS. A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13668-73.
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Goodman T, Crandall JE, Nanescu SE, Quadro L, Shearer K, Ross A, McCaffery P. Patterning of retinoic acid signaling and cell proliferation in the hippocampus. Hippocampus. 2012 Nov; 22(11):2171-83.
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Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, Isoherranen N. Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. Mol Pharmacol. 2011 Aug; 80(2):228-39.
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Sakai Y, Luo T, McCaffery P, Hamada H, Dr?ger UC. CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development. Dev Biol. 2004 Dec 01; 276(1):143-57.
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Zhelyaznik N, Schrage K, McCaffery P, Mey J. Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins. Eur J Neurosci. 2003 Sep; 18(5):1033-40.
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Zhang J, Smith D, Yamamoto M, Ma L, McCaffery P. The meninges is a source of retinoic acid for the late-developing hindbrain. J Neurosci. 2003 Aug 20; 23(20):7610-20.