Click Chemistry

"Click Chemistry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.

Descriptor ID	D057930
MeSH Number(s)	E05.197.124 J01.897.836.249.124
Concept/Terms	Click Chemistry Click Chemistry Chemistries, Click Chemistry, Click Click Chemistries Click Chemical Techniques Chemical Technique, Click Chemical Techniques, Click Click Chemical Technique Technique, Click Chemical Techniques, Click Chemical Click Chemical Reactions Click Chemical Reactions Chemical Reaction, Click Chemical Reactions, Click Click Chemical Reaction Reaction, Click Chemical Reactions, Click Chemical

Below are MeSH descriptors whose meaning is more general than "Click Chemistry".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Chemistry Techniques, Synthetic [E05.197]
Click Chemistry [E05.197.124]
Technology, Industry, Agriculture [J]
Technology, Industry, and Agriculture [J01]
Technology [J01.897]
Technology, Pharmaceutical [J01.897.836]
Chemistry Techniques, Synthetic [J01.897.836.249]
Click Chemistry [J01.897.836.249.124]

Below are MeSH descriptors whose meaning is related to "Click Chemistry".

Below are MeSH descriptors whose meaning is more specific than "Click Chemistry".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Click Chemistry" by people in this website by year, and whether "Click Chemistry" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 2 publications in 2020 and 2021 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	0	1
2017	1	0	1
2018	0	1	1
2020	2	0	2
2021	1	1	2
2024	1	1	2

Below are the most recent publications written about "Click Chemistry" by people in Profiles.

Banahene N, Peters-Clarke TM, Biegas KJ, Shishkova E, Hart EM, McKitterick AC, Kambitsis NH, Johnson UG, Bernhardt TG, Coon JJ, Swarts BM. Chemical Proteomics Strategies for Analyzing Protein Lipidation Reveal the Bacterial O-Mycoloylome. J Am Chem Soc. 2024 05 01; 146(17):12138-12154.

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Sun XL, Xue H, Gu XY, Li DS, Xiao H, Wan WM. Clickable Polymerization-Induced Emission Luminogens Toward Color-Tunable Modification of Non-Traditional Intrinsic Luminescent Polymers. Macromol Rapid Commun. 2024 Jun; 45(11):e2400045.

View in: PubMed
van Hest J, Zheng G, Rotello VM. Bioorthogonal Chemistry and Bioconjugation: Synergistic Tools for Biology and Biomedicine. Bioconjug Chem. 2021 08 18; 32(8):1409-1410.

View in: PubMed
Gao R, Yu CJ, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES. A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy. Nat Nanotechnol. 2021 06; 16(6):698-707.

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Liu B, Wu R, Gong S, Xiao H, Thayumanavan S. In Situ Formation of Polymeric Nanoassemblies Using an Efficient Reversible Click Reaction. Angew Chem Int Ed Engl. 2020 08 24; 59(35):15135-15140.

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Kavunja HW, Biegas KJ, Banahene N, Stewart JA, Piligian BF, Groenevelt JM, Sein CE, Morita YS, Niederweis M, Siegrist MS, Swarts BM. Photoactivatable Glycolipid Probes for Identifying Mycolate-Protein Interactions in Live Mycobacteria. J Am Chem Soc. 2020 04 29; 142(17):7725-7731.

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Nemmara VV, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR. The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs). ACS Chem Biol. 2018 03 16; 13(3):712-722.

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Tyler DS, Vappiani J, Ca?eque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 06 30; 356(6345):1397-1401.

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Xu J, Filion TM, Prifti F, Song J. Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. Chem Asian J. 2011 Oct 04; 6(10):2730-7.

View in: PubMed

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