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A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments.
Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.
Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection.
Implementing a tuberculosis child contact register to quantify children at risk for tuberculosis and HIV in Eldoret, Kenya.
Mutational fitness landscape and drug resistance.
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Mutational fitness landscape and drug resistance.
Flynn J, Samant N, Schneider-Nachum G, Tenzin T, Bolon DNA. Mutational fitness landscape and drug resistance. Curr Opin Struct Biol. 2023 02; 78:102525.
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PubMed
subject areas
Drug Resistance
Genetic Fitness
Models, Genetic
Mutation
Proteins
authors with profiles
Daniel N Bolon PhD