Genetic Fitness

"Genetic Fitness" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.

Descriptor ID	D056084
MeSH Number(s)	G05.347
Concept/Terms	Genetic Fitness Genetic Fitness Fitness, Genetic Darwinian Fitness Darwinian Fitness Fitness, Darwinian Reproductive Fitness Reproductive Fitness Fitness, Reproductive

Below are MeSH descriptors whose meaning is more general than "Genetic Fitness".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Fitness [G05.347]

Below are MeSH descriptors whose meaning is related to "Genetic Fitness".

Below are MeSH descriptors whose meaning is more specific than "Genetic Fitness".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Fitness" by people in this website by year, and whether "Genetic Fitness" was a major or minor topic of these publications.

Bar chart showing 24 publications over 13 distinct years, with a maximum of 3 publications in 2013 and 2014 and 2020 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2011	0	1	1
2012	1	0	1
2013	2	1	3
2014	2	1	3
2016	0	2	2
2017	0	2	2
2018	2	0	2
2020	1	2	3
2021	2	1	3
2022	1	0	1
2023	1	0	1
2025	1	0	1

Below are the most recent publications written about "Genetic Fitness" by people in Profiles.

Luna MJ, Oluoch PO, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, Shell SS, Ioerger TR, Fortune SM, Farhat MR, Sassetti CM. Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures. mBio. 2025 Mar 12; 16(3):e0376224.

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Flynn J, Samant N, Schneider-Nachum G, Tenzin T, Bolon DNA. Mutational fitness landscape and drug resistance. Curr Opin Struct Biol. 2023 02; 78:102525.

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Obermeyer F, Jankowiak M, Barkas N, Schaffner SF, Pyle JD, Yurkovetskiy L, Bosso M, Park DJ, Babadi M, MacInnis BL, Luban J, Sabeti PC, Lemieux JE. Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness. Science. 2022 06 17; 376(6599):1327-1332.

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Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J, Lytras S, Czudnochowski N, Shah R, Meury M, Jesudason N, De Marco A, Li K, Bassi J, O'Toole A, Pinto D, Colquhoun RM, Culap K, Jackson B, Zatta F, Rambaut A, Jaconi S, Sreenu VB, Nix J, Zhang I, Jarrett RF, Glass WG, Beltramello M, Nomikou K, Pizzuto M, Tong L, Cameroni E, Croll TI, Johnson N, Di Iulio J, Wickenhagen A, Ceschi A, Harbison AM, Mair D, Ferrari P, Smollett K, Sallusto F, Carmichael S, Garzoni C, Nichols J, Galli M, Hughes J, Riva A, Ho A, Schiuma M, Semple MG, Openshaw PJM, Fadda E, Baillie JK, Chodera JD, Rihn SJ, Lycett SJ, Virgin HW, Telenti A, Corti D, Robertson DL, Snell G. Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell. 2021 03 04; 184(5):1171-1187.e20.

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Cote-Hammarlof PA, Fragata I, Flynn J, Mavor D, Zeldovich KB, Bank C, Bolon DNA. The Adaptive Potential of the Middle Domain of Yeast Hsp90. Mol Biol Evol. 2021 01 23; 38(2):368-379.

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Lozovsky ER, Daniels RF, Heffernan GD, Jacobus DP, Hartl DL. Relevance of Higher-Order Epistasis in Drug Resistance. Mol Biol Evol. 2021 01 04; 38(1):142-151.

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Jeon KH, Shin DW, Han K, Kim D, Yoo JE, Jeong SM, Cho JH. Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study. Br J Cancer. 2020 04; 122(9):1417-1424.

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Flynn JM, Rossouw A, Cote-Hammarlof P, Fragata I, Mavor D, Hollins C, Bank C, Bolon DN. Comprehensive fitness maps of Hsp90 show widespread environmental dependence. Elife. 2020 03 04; 9.

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Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 02 01; 37(2):320-326.

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Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA. Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness. J Mol Biol. 2018 04 13; 430(8):1098-1115.

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