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Brian W Labadie MD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine at UMass Chan - Lahey
AddressLahey Hospital and Medical Center
41 Mall Road
Burlington MA 01805
Phone781-744-8630
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine at UMass Chan - Lahey


    Collapse Biography 
    Collapse education and training
    University of California, San Diego, San Diego, CA, United StatesBSBiochemistry & Cell Biology
    University of California, Irvine, Irvine, CA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fojo AT, Labadie B. Harvesting information from Kaplan-Meier plots: part 1-detecting censoring. Oncologist. 2024 Jul 05; 29(7):551-553. PMID: 38842753.
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    2. Ehrlich MI, Hughes MS, Labadie BW, Siegelin MD, D'Ovidio F, Bijou R, Lentzsch S, Arcasoy SM. Lung Transplantation for Pulmonary AL Amyloidosis. Transplant Direct. 2024 Mar; 10(3):e1577. PMID: 38380351.
      Citations:    
    3. Ehrlich MI, Labadie BW, Bates SE, Fojo T. Mitotane and the myth of 14 mg/L. Lancet Oncol. 2024 Jan; 25(1):12-15. PMID: 38181804.
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    4. Chaudagar K, Hieromnimon HM, Kelley A, Labadie B, Shafran J, Rameshbabu S, Drovetsky C, Bynoe K, Solanki A, Markiewicz E, Fan X, Loda M, Patnaik A. Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis. Clin Cancer Res. 2023 12 01; 29(23):4930-4940. PMID: 37721526.
      Citations:    
    5. Chaudagar K, Rameshbabu S, Mei S, Hirz T, Hu YM, Argulian A, Labadie B, Desai K, Grimaldo S, Kahramangil D, Nair R, DSouza S, Zhou D, Li M, Doughan F, Chen R, Shafran J, Loyd M, Xia Z, Sykes DB, Moran A, Patnaik A. Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis. bioRxiv. 2023 Oct 21. PMID: 37904975.
      Citations:    
    6. Labadie BW, Fojo AT. In Defense of Neuroendocrine Tumor Trials-Reply. JAMA Oncol. 2023 Oct 01; 9(10):1464-1465. PMID: 37615959.
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    7. Chaudagar K, Hieromnimon HM, Kelley A, Labadie B, Shafran J, Rameshbabu S, Drovetsky C, Bynoe K, Solanki A, Markiewicz E, Fan X, Loda M, Patnaik A. Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis. bioRxiv. 2023 May 23. PMID: 37292972.
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    8. Chaudagar K, Hieromnimon HM, Khurana R, Labadie B, Hirz T, Mei S, Hasan R, Shafran J, Kelley A, Apostolov E, Al-Eryani G, Harvey K, Rameshbabu S, Loyd M, Bynoe K, Drovetsky C, Solanki A, Markiewicz E, Zamora M, Fan X, Sch?rer S, Swarbrick A, Sykes DB, Patnaik A. Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer. Clin Cancer Res. 2023 05 15; 29(10):1952-1968. PMID: 36862086.
      Citations:    
    9. Labadie BW, Fojo AT. Requirements for Meaningful Progress in the Therapy of Neuroendocrine Cancers. JAMA Oncol. 2023 05 01; 9(5):606-608. PMID: 36892851.
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    10. Labadie BW, Morris DS, Bryce AH, Given R, Zhang J, Abida W, Chowdhury S, Patnaik A. Guidelines for Management of Treatment-Emergent Adverse Events During Rucaparib Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer. Cancer Manag Res. 2022; 14:673-686. PMID: 35210863.
      Citations:    
    11. Labadie BW, Balar AV, Luke JJ. Immune Checkpoint Inhibitors for Genitourinary Cancers: Treatment Indications, Investigational Approaches and Biomarkers. Cancers (Basel). 2021 Oct 28; 13(21). PMID: 34771578.
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    12. Olson DJ, Eroglu Z, Brockstein B, Poklepovic AS, Bajaj M, Babu S, Hallmeyer S, Velasco M, Lutzky J, Higgs E, Bao R, Carll TC, Labadie B, Krausz T, Zha Y, Karrison T, Sondak VK, Gajewski TF, Khushalani NI, Luke JJ. Pembrolizumab Plus Ipilimumab Following Anti-PD-1/L1 Failure in Melanoma. J Clin Oncol. 2021 08 20; 39(24):2647-2655. PMID: 33945288.
      Citations:    
    13. Rameshbabu S, Labadie BW, Argulian A, Patnaik A. Targeting Innate Immunity in Cancer Therapy. Vaccines (Basel). 2021 Feb 09; 9(2). PMID: 33572196.
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    14. Bao R, Surriga O, Olson DJ, Allred JB, Strand CA, Zha Y, Carll T, Labadie BW, Bastos BR, Butler M, Hogg D, Musi E, Ambrosini G, Munster P, Schwartz GK, Luke JJ. Transcriptional analysis of metastatic uveal melanoma survival nominates NRP1 as a therapeutic target. Melanoma Res. 2021 02 01; 31(1):27-37. PMID: 33170593.
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    15. Labadie BW, Liu P, Bao R, Crist M, Fernandes R, Ferreira L, Graupner S, Poklepovic AS, Duran I, Maleki Vareki S, Balar AV, Luke JJ. BMI, irAE, and gene expression signatures associate with resistance to immune-checkpoint inhibition and outcomes in renal cell carcinoma. J Transl Med. 2019 11 25; 17(1):386. PMID: 31767020.
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    16. Luke JJ, Olson DJ, Allred JB, Strand CA, Bao R, Zha Y, Carll T, Labadie BW, Bastos BR, Butler MO, Hogg D, Munster PN, Schwartz GK. Randomized Phase II Trial and Tumor Mutational Spectrum Analysis from Cabozantinib versus Chemotherapy in Metastatic Uveal Melanoma (Alliance A091201). Clin Cancer Res. 2020 02 15; 26(4):804-811. PMID: 31558480.
      Citations:    
    17. Labadie BW, Bao R, Luke JJ. Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan-Kynurenine-Aryl Hydrocarbon Axis. Clin Cancer Res. 2019 03 01; 25(5):1462-1471. PMID: 30377198.
      Citations:    
    18. Ankeny JS, Labadie B, Luke J, Hsueh E, Messina J, Zager JS. Review of diagnostic, prognostic, and predictive biomarkers in melanoma. Clin Exp Metastasis. 2018 08; 35(5-6):487-493. PMID: 29722000.
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    19. Shah S, Wood K, Labadie B, Won B, Brisson R, Karrison T, Hensing T, Kozloff M, Bao R, Patel JD, Luke JJ. Clinical and molecular features of innate and acquired resistance to anti-PD-1/PD-L1 therapy in lung cancer. Oncotarget. 2018 Jan 12; 9(4):4375-4384. PMID: 29435109.
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    20. Labadie B, Patel RM, Gandy Labadie J, Hwang C, Okhunov Z, Landman J. Assessing the Effect of an Intensive 2-Week Surgical Training and Innovation Program for High-School Students. J Surg Educ. 2017 Nov - Dec; 74(6):958-967. PMID: 28625495.
      Citations:    
    21. Gandy J, Labadie B, Bierman D, Zachary C. Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time. J Drugs Dermatol. 2017 Mar 01; 16(3):275-278. PMID: 28301624.
      Citations:    
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