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Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation.
Serine
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice.
The surprising discovery that TGF beta specifically induces the IgA class switch.
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The surprising discovery that TGF beta specifically induces the IgA class switch.
Stavnezer J, Kang J. The surprising discovery that TGF beta specifically induces the IgA class switch. J Immunol. 2009 Jan 01; 182(1):5-7.
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PubMed
subject areas
Animals
B-Lymphocytes
Gene Rearrangement, B-Lymphocyte
History, 20th Century
History, 21st Century
Humans
Immunoglobulin A
Immunoglobulin Class Switching
Mice
Recombination, Genetic
Transforming Growth Factor beta
authors with profiles
Joonsoo Kang PhD
Janet Stavnezer PhD