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Guertin, David

One or more keywords matched the following items that are connected to Guertin, David

Item Type	Name
Academic Article	The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.
Academic Article	Cytokinesis in eukaryotes.
Academic Article	Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).
Academic Article	Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex.
Academic Article	Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Academic Article	An expanding role for mTOR in cancer.
Academic Article	Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Academic Article	Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p.
Academic Article	The pharmacology of mTOR inhibition.
Academic Article	mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Academic Article	Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Academic Article	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Academic Article	Functional genomics identifies TOR-regulated genes that control growth and division.
Academic Article	Defining the role of mTOR in cancer.
Academic Article	mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Academic Article	Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Academic Article	Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics.
Academic Article	Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.
Academic Article	Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Academic Article	PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.
Academic Article	mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Academic Article	mTOR-dependent cell survival mechanisms.
Concept	Cyclin-Dependent Kinases
Concept	Protein Kinase Inhibitors
Concept	Ribosomal Protein S6 Kinases
Concept	Protein Kinases
Concept	Protein Kinase C
Concept	Phosphotransferases (Alcohol Group Acceptor)
Concept	Glycogen Synthase Kinase 3
Concept	Protein Kinase C-alpha
Concept	Phosphotransferases
Concept	Phosphatidylinositol 3-Kinases
Academic Article	T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.
Academic Article	Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.
Academic Article	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Academic Article	Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.
Concept	Glycogen Synthase Kinase 3 beta
Concept	TOR Serine-Threonine Kinases
Concept	3-Phosphoinositide-Dependent Protein Kinases
Academic Article	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

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Phosphotransferases