 Parathyroid Hormone-Related Protein
"Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
| Descriptor ID |
D044162
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| MeSH Number(s) |
D06.472.699.591 D12.644.276.908 D12.644.548.588 D12.776.467.890 D23.529.890
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| Concept/Terms |
Parathyroid Hormone-Related Protein- Parathyroid Hormone-Related Protein
- Hormone-Related Protein, Parathyroid
- Parathyroid Hormone Related Protein
- Parathyroid Hormone-Like Protein
- Parathyroid Hormone Like Protein
- Parathyroid Hormone-Related Peptide
- Parathyroid Hormone Related Peptide
- PTHrP
- Tumor Hypercalcemic Factor
- Hypercalcemic Factor, Tumor
- Hypercalcemic Hormone of Malignancy
- PTH Like Tumor Factor
- PTH-Like Protein
- PTH Like Protein
- Parathyroid Hormone Like Tumor Factor
- PTH-Related Peptide
- PTH Related Peptide
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Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone-Related Protein".
Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone-Related Protein".
This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website by year, and whether "Parathyroid Hormone-Related Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Parathyroid Hormone-Related Protein" by people in Profiles.
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Li J, Sun H, Feltri ML, Mercurio AM. Integrin ß4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15; 407(2):313-20.
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Otero JE, Stevens JW, Malandra AE, Fredericks DC, Odgren PR, Buckwalter JA, Morcuende J. Osteoclast inhibition impairs chondrosarcoma growth and bone destruction. J Orthop Res. 2014 Dec; 32(12):1562-71.
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Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, FitzGerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR. Integrin avß6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014 Mar 1; 74(5):1598-608.
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Tohmonda T, Yoda M, Mizuochi H, Morioka H, Matsumoto M, Urano F, Toyama Y, Horiuchi K. The IRE1a-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis. J Biol Chem. 2013 Jan 18; 288(3):1691-5.
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Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46.
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Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res. 2008 Oct 1; 68(19):7795-802.
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Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51.
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Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. J Cell Biochem. 2005 Aug 1; 95(5):1057-68.
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Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res. 2004 Sep 10; 299(1):128-36.
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Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 2004 Mar; 198(3):428-40.
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