Parathyroid Hormone-Related Protein

"Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.

Descriptor ID	D044162
MeSH Number(s)	D06.472.699.591 D12.644.276.908 D12.644.548.588 D12.776.467.890 D23.529.890
Concept/Terms	Parathyroid Hormone-Related Protein Parathyroid Hormone-Related Protein Hormone-Related Protein, Parathyroid Parathyroid Hormone Related Protein Parathyroid Hormone-Like Protein Parathyroid Hormone Like Protein Parathyroid Hormone-Related Peptide Parathyroid Hormone Related Peptide PTHrP Tumor Hypercalcemic Factor Hypercalcemic Factor, Tumor Hypercalcemic Hormone of Malignancy PTH Like Tumor Factor PTH-Like Protein PTH Like Protein Parathyroid Hormone Like Tumor Factor PTH-Related Peptide PTH Related Peptide

Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone-Related Protein".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Parathyroid Hormone-Related Protein [D06.472.699.591]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Parathyroid Hormone-Related Protein [D12.644.276.908]
Peptide Hormones [D12.644.548]
Parathyroid Hormone-Related Protein [D12.644.548.588]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Parathyroid Hormone-Related Protein [D12.776.467.890]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Parathyroid Hormone-Related Protein [D23.529.890]

Below are MeSH descriptors whose meaning is related to "Parathyroid Hormone-Related Protein".

Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone-Related Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website by year, and whether "Parathyroid Hormone-Related Protein" was a major or minor topic of these publications.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 2008 and 2009 and 2014 and 2015 and 2016 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	1	0	1
2014	0	1	1
2015	1	0	1
2016	0	1	1
2021	1	0	1

Below are the most recent publications written about "Parathyroid Hormone-Related Protein" by people in Profiles.

Pitarresi JR, Norgard RJ, Chiarella AM, Suzuki K, Bakir B, Sahu V, Li J, Zhao J, Marchand B, Wengyn MD, Hsieh A, Kim IK, Zhang A, Sellin K, Lee V, Takano S, Miyahara Y, Ohtsuka M, Maitra A, Notta F, Kremer R, Stanger BZ, Rustgi AK. PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability. Cancer Discov. 2021 07; 11(7):1774-1791.

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Taipaleenm?ki H, Farina NH, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Oncotarget. 2016 Nov 29; 7(48):79032-79046.

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Li J, Sun H, Feltri ML, Mercurio AM. Integrin ?4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15; 407(2):313-20.

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Otero JE, Stevens JW, Malandra AE, Fredericks DC, Odgren PR, Buckwalter JA, Morcuende J. Osteoclast inhibition impairs chondrosarcoma growth and bone destruction. J Orthop Res. 2014 Dec; 32(12):1562-71.

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Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, FitzGerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR. Integrin av?6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014 Mar 01; 74(5):1598-608.

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Tohmonda T, Yoda M, Mizuochi H, Morioka H, Matsumoto M, Urano F, Toyama Y, Horiuchi K. The IRE1a-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis. J Biol Chem. 2013 Jan 18; 288(3):1691-5.

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Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46.

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Rosenblatt M. When two keys fit one lock, surprises follow. Nat Chem Biol. 2009 Oct; 5(10):707-8.

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Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res. 2008 Oct 01; 68(19):7795-802.

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Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51.

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