Eukaryotic Initiation Factor-2

"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.

Descriptor ID	D015852
MeSH Number(s)	D12.776.835.725.868.249
Concept/Terms	Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor 2 Initiation Factor-2, Eukaryotic Peptide Initiation Factor EIF-2 Peptide Initiation Factor EIF 2 Eukaryotic Peptide Initiation Factor-2 Eukaryotic Peptide Initiation Factor 2 EIF-2 EIF 2 EIF2 Eukaryotic Initiation Factor-2, beta Subunit Eukaryotic Initiation Factor-2, beta Subunit Eukaryotic Initiation Factor 2, beta Subunit EIF-2beta EIF 2beta EIF-2 beta EIF 2 beta Eukaryotic Initiation Factor-2, gamma Subunit Eukaryotic Initiation Factor-2, gamma Subunit Eukaryotic Initiation Factor 2, gamma Subunit EIF-2gamma EIF 2gamma EIF-2 gamma EIF 2 gamma Eukaryotic Initiation Factor-2, alpha Subunit Eukaryotic Initiation Factor-2, alpha Subunit Eukaryotic Initiation Factor 2, alpha Subunit EIF-2alpha EIF 2alpha EIF-2 alpha EIF 2 alpha

Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Ribosomal Proteins [D12.776.835]
Peptide Initiation Factors [D12.776.835.725]
Eukaryotic Initiation Factors [D12.776.835.725.868]
Eukaryotic Initiation Factor-2 [D12.776.835.725.868.249]

Below are MeSH descriptors whose meaning is related to "Eukaryotic Initiation Factor-2".

Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in this website by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publications.

Bar chart showing 13 publications over 10 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2001	1	1	2
2002	0	1	1
2003	1	0	1
2004	0	1	1
2008	1	0	1
2009	1	2	3
2010	1	0	1
2018	1	0	1
2025	0	1	1

Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.

Cicu?ndez B, Mora A, L?pez JA, Curtabbi A, P?rez-Garc?a J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, G?mez-Santos B, Romero-Becerra R, Leiva M, Rodr?guez E, Le?n M, Leiva-Vega L, G?mez-Lado N, Torres JL, Hern?ndez-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bola?os JP, Spinelli JB, Puigserver P, Enriquez JA, V?zquez J, Folgueira C, Sabio G. Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis. Nat Commun. 2025 Jan 13; 16(1):229.

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Cagnetta R, Wong HH, Frese CK, Mallucci GR, Krijgsveld J, Holt CE. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. Mol Cell. 2019 02 07; 73(3):474-489.e5.

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Dias-Teixeira KL, Calegari-Silva TC, Medina JM, Vivarini ?C, Cavalcanti ?, Teteo N, Santana AKM, Real F, Gomes CM, Pereira RMS, Fasel N, Silva JS, Aktas BH, Lopes UG. Emerging Role for the PERK/eIF2a/ATF4 in Human Cutaneous Leishmaniasis. Sci Rep. 2017 12 06; 7(1):17074.

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Olou AA, Sarkar A, Bele A, Gurumurthy CB, Mir RA, Ammons SA, Mirza S, Saleem I, Urano F, Band H, Band V. Mammalian ECD Protein Is a Novel Negative Regulator of the PERK Arm of the Unfolded Protein Response. Mol Cell Biol. 2017 Sep 15; 37(18).

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Konsavage WM, Zhang L, Wu Y, Shenberger JS. Hyperoxia-induced activation of the integrated stress response in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L27-35.

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Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson ND, Wolfe SA, Giraldez AJ. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science. 2010 Jun 25; 328(5986):1694-8.

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Konsavage W, Zhang L, Vary T, Shenberger JS. Hyperoxia inhibits protein synthesis and increases eIF2a phosphorylation in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L678-86.

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Costa-Mattioli M, Sonenberg N, Richter JD. Translational regulatory mechanisms in synaptic plasticity and memory storage. Prog Mol Biol Transl Sci. 2009; 90:293-311.

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Trombly MI, Su H, Wang X. A genetic screen for components of the mammalian RNA interference pathway in Bloom-deficient mouse embryonic stem cells. Nucleic Acids Res. 2009 Mar; 37(4):e34.

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Su H, Trombly MI, Chen J, Wang X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 01; 23(3):304-17.

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