 Necrosis
"Necrosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.
| Descriptor ID |
D009336
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| MeSH Number(s) |
C23.550.717 G04.299.139.638
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Necrosis".
Below are MeSH descriptors whose meaning is more specific than "Necrosis".
This graph shows the total number of publications written about "Necrosis" by people in this website by year, and whether "Necrosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1986 | 0 | 2 | 2 | | 1988 | 1 | 1 | 2 | | 1990 | 0 | 1 | 1 | | 1992 | 0 | 2 | 2 | | 1995 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 3 | 3 | | 2003 | 1 | 5 | 6 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 3 | 3 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 5 | 6 | | 2009 | 0 | 4 | 4 | | 2010 | 0 | 5 | 5 | | 2011 | 1 | 5 | 6 | | 2012 | 0 | 5 | 5 | | 2013 | 0 | 4 | 4 | | 2014 | 4 | 5 | 9 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Necrosis" by people in Profiles.
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Khedr S, Piskorski A, Bingham AR, Goldstein J, Laptook AR, De Paepe ME. Occult Massive Visceral Fat Necrosis Following Therapeutic Hypothermia for Neonatal Encephalopathy. Pediatr Dev Pathol. 2018 Sep-Oct; 21(5):502-506.
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Chin MS, Chappell AG, Giatsidis G, Perry DJ, Lujan-Hernandez J, Haddad A, Matsumine H, Orgill DP, Lalikos JF. Hyperspectral Imaging Provides Early Prediction of Random Axial Flap Necrosis in a Preclinical Model. Plast Reconstr Surg. 2017 Jun; 139(6):1285e-1290e.
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Galluzzi L, Kepp O, Chan FK, Kroemer G. Necroptosis: Mechanisms and Relevance to Disease. Annu Rev Pathol. 2017 Jan 24; 12:103-130.
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Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016 Aug 5; 353(6299):603-8.
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Thompson CC, Kumar N, Slattery J, Clancy TE, Ryan MB, Ryou M, Swanson RS, Banks PA, Conwell DL. A standardized method for endoscopic necrosectomy improves complication and mortality rates. Pancreatology. 2016 Jan-Feb; 16(1):66-72.
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Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH. Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. Am J Surg Pathol. 2015 Aug; 39(8):1121-31.
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Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16; 520(7547):363-7.
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Quinn C, Salameh JS, Smith T, Souayah N. Necrotizing myopathies: an update. J Clin Neuromuscul Dis. 2015 Mar; 16(3):131-40.
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Moriwaki K, Bertin J, Gough PJ, Orlowski GM, Chan FK. Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis. 2015 Feb 12; 6:e1636.
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Chan FK, Luz NF, Moriwaki K. Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol. 2015; 33:79-106.
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