Blood-Brain Barrier

"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

Descriptor ID	D001812
MeSH Number(s)	A07.035 A08.186.211.035
Concept/Terms	Blood-Brain Barrier Blood-Brain Barrier Barrier, Blood-Brain Barriers, Blood-Brain Blood Brain Barrier Blood-Brain Barriers Hemato-Encephalic Barrier Barrier, Hemato-Encephalic Barriers, Hemato-Encephalic Hemato Encephalic Barrier Hemato-Encephalic Barriers Brain-Blood Barrier Barrier, Brain-Blood Barriers, Brain-Blood Brain Blood Barrier Brain-Blood Barriers

Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".

Anatomy [A]
Cardiovascular System [A07]
Blood-Brain Barrier [A07.035]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Blood-Brain Barrier [A08.186.211.035]

Below are MeSH descriptors whose meaning is related to "Blood-Brain Barrier".

Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.

Bar chart showing 77 publications over 24 distinct years, with a maximum of 9 publications in 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2002	1	0	1
2003	1	0	1
2005	1	0	1
2006	0	1	1
2007	0	1	1
2008	1	1	2
2009	0	1	1
2010	0	4	4
2011	3	5	8
2012	3	1	4
2013	1	4	5
2014	0	5	5
2015	1	4	5
2017	1	3	4
2018	3	0	3
2019	2	0	2
2020	2	3	5
2021	1	0	1
2022	1	1	2
2023	4	5	9
2024	3	1	4
2025	3	2	5
2026	1	1	2

Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.

Wayne CR, Akcan U, Faust TE, Durán-Laforet V, Jamoul D, Bremner L, Ampatey N, Akcan BT, Ho SJ, Ciric B, Delaney SL, Vargas WS, Swedo S, Menon V, Schafer DP, Cutforth T, Agalliu D. Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis. Nat Commun. 2026 08 11; 17(1).

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Boardman SA, Hetherington C, Hughes T, Cook C, Galea I, Hilton O, Solomon T, Luster AD, Allan S, Kurt-Jones E, Forth J, Patabendige A, Egbe FN, Dunai C, Michael BD. Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies. J Infect Dis. 2025 Dec 20; 232(6):1273-1282.

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Benatti HR, Taghian T, Mihalek O, Nath S, Gallagher J, McElroy A, Hall EF, Daci R, Yingling NK, Baker WC, Tuominen S, Bierfeldt L, Jiang X, Gray-Edwards HL, Sirianni RW. Cerebrospinal Fluid Flow Enhancement (CFE) Increases the Spatial Distribution of Methotrexate after Intracerebroventricular Administration in a Sheep Model. Mol Pharm. 2025 07 07; 22(7):3654-3665.

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Daci R, Flotte TR. Delivery of Adeno-Associated Virus Vectors to the Central Nervous System for Correction of Single Gene Disorders. Int J Mol Sci. 2024 Jan 15; 25(2).

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Bricio-Moreno L, Kurt-Jones EA, Sorensen EW, Luster AD, Michael BD. Using Multiphoton Intravital Microscopy to Study Neutrophil Transmigration and Blood-Brain Barrier Permeability in a Mouse Model of Herpes Simplex Virus Encephalitis. Methods Mol Biol. 2024; 2828:45-55.

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Alves SAS, Teixeira DE, Peruchetti DB, Silva LS, Brandão LFP, Caruso-Neves C, Pinheiro AAS. Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells. Brain Res. 2024 01 01; 1822:148669.

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Zhang W, Oh JH, Zhang W, Rathi S, Larson JD, Wechsler-Reya RJ, Sirianni RW, Elmquist WF. Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors. J Pharmacol Exp Ther. 2023 12; 387(3):315-327.

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Goldwaser EL, Wang DJJ, Adhikari BM, Chiappelli J, Shao X, Yu J, Lu T, Chen S, Marshall W, Yuen A, Kvarta M, Ma Y, Du X, Gao S, Saeedi O, Bruce H, Donnelly P, O'Neill H, Shuldiner AR, Mitchell BD, Kochunov P, Hong LE. Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study. Schizophr Bull. 2023 09 07; 49(5):1325-1335.

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Sun A, Hagenbuch B, Kelly EJ, Wang J. Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Mol Pharmacol. 2023 12; 104(6):255-265.

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Li Y, Ying Y, Yao T, Jia X, Liang H, Tang W, Jia X, Song H, Shao X, Wang DJJ, Wang C, Cheng X, Yang Q. Decreased water exchange rate across blood-brain barrier in hereditary cerebral small vessel disease. Brain. 2023 07 03; 146(7):3079-3087.

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