"Caspase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
- Caspase 9
- ICE-Like Apoptotic Protease 6
- ICE Like Apoptotic Protease 6
- Apoptotic Protease Activating Factor 3
- ICE-LAP6 Protein
- ICE LAP6 Protein
- Procaspase 9
- Pro Caspase 9
Below are MeSH descriptors whose meaning is more general than "Caspase 9".
Below are MeSH descriptors whose meaning is more specific than "Caspase 9".
This graph shows the total number of publications written about "Caspase 9" by people in this website by year, and whether "Caspase 9" was a major or minor topic of these publications.
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Below are the most recent publications written about "Caspase 9" by people in Profiles.
Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. ACS Chem Biol. 2021 11 19; 16(11):2280-2296.
Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. 2021 09 21; 60(37):2824-2835.
Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD?:?core domain interactions require a properly formed active site. Biochem J. 2018 03 29; 475(6):1177-1196.
Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core. Cell Death Differ. 2018 06; 25(6):1025-1039.
Serrano BP, Szydlo HS, Alfandari D, Hardy JA. Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. J Biol Chem. 2017 12 29; 292(52):21352-21365.
Kamber Kaya HE, Ditzel M, Meier P, Bergmann A. An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways. PLoS Genet. 2017 02; 13(2):e1006438.
Eron SJ, Raghupathi K, Hardy JA. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure. 2017 01 03; 25(1):27-39.
Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods. 2015 May; 12(5):401-403.
Sun YR, Zhang SH, Shao RG, He HW. [The synergistic effect of lidamycin and rituximab on human B cell lymphoma]. Yao Xue Xue Bao. 2014 Feb; 49(2):198-203.
Huber KL, Hardy JA. Mechanism of zinc-mediated inhibition of caspase-9. Protein Sci. 2012 Jul; 21(7):1056-65.