Caspases, Initiator

"Caspases, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.

Descriptor ID	D053471
MeSH Number(s)	D08.811.277.656.262.500.126.550 D08.811.277.656.300.200.126.550 D12.644.360.075.405.550 D12.776.476.075.405.550
Concept/Terms	Caspases, Initiator Caspases, Initiator Initiator Caspases

Below are MeSH descriptors whose meaning is more general than "Caspases, Initiator".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Cysteine Proteases [D08.811.277.656.262]
Cysteine Endopeptidases [D08.811.277.656.262.500]
Caspases [D08.811.277.656.262.500.126]
Caspases, Initiator [D08.811.277.656.262.500.126.550]
Endopeptidases [D08.811.277.656.300]
Cysteine Endopeptidases [D08.811.277.656.300.200]
Caspases [D08.811.277.656.300.200.126]
Caspases, Initiator [D08.811.277.656.300.200.126.550]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Caspases [D12.644.360.075.405]
Caspases, Initiator [D12.644.360.075.405.550]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Caspases [D12.776.476.075.405]
Caspases, Initiator [D12.776.476.075.405.550]

Below are MeSH descriptors whose meaning is related to "Caspases, Initiator".

Below are MeSH descriptors whose meaning is more specific than "Caspases, Initiator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Caspases, Initiator" by people in this website by year, and whether "Caspases, Initiator" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2013 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2012	0	1	1
2013	0	2	2
2014	0	1	1
2015	0	1	1
2017	0	1	1
2020	0	2	2
2025	1	0	1

Below are the most recent publications written about "Caspases, Initiator" by people in Profiles.

Braun T, Afgin N, Sapozhnikov L, Sivan E, Bergmann A, Baena-Lopez LA, Yacobi-Sharon K, Arama E. Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc. Nat Commun. 2025 Dec 04; 16(1):10871.

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Krause K, Franch Arroyo S, Ugolini M, Kueck T, Sullivan TJ, G?lvez EJC, Muenzner M, Goosmann C, Brinkmann V, Frese CK, Alagesan K, Vierbuchen T, Heine H, Resch U, Sander LE, Charpentier E. Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes. EMBO Rep. 2025 Oct; 26(19):4847-4885.

View in: PubMed
Finethy R, Dockterman J, Kutsch M, Orench-Rivera N, Wallace GD, Piro AS, Luoma S, Haldar AK, Hwang S, Martinez J, Kuehn MJ, Taylor GA, Coers J. Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020 11 05; 21(11):e50830.

View in: PubMed
Tian Y, Qu S, Alam HB, Williams AM, Wu Z, Deng Q, Pan B, Zhou J, Liu B, Duan X, Ma J, Mondal S, Thompson PR, Stringer KA, Standiford TJ, Li Y. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020 10 15; 5(20).

View in: PubMed
Finethy R, Luoma S, Orench-Rivera N, Feeley EM, Haldar AK, Yamamoto M, Kanneganti TD, Kuehn MJ, Coers J. Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. mBio. 2017 10 03; 8(5).

View in: PubMed
Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. Infect Immun. 2015 Dec; 83(12):4740-9.

View in: PubMed
Eltom S, Belvisi MG, Yew-Booth L, Dekkak B, Maher SA, Dubuis ED, Jones V, Fitzgerald KA, Birrell MA. TLR4 activation induces IL-1? release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung. Respir Res. 2014 Aug 02; 15:87.

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Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production. J Immunol. 2013 Nov 15; 191(10):5239-46.

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Rathinam VA, Fitzgerald KA. Immunology: Lipopolysaccharide sensing on the inside. Nature. 2013 Sep 12; 501(7466):173-5.

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Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell. 2012 Aug 03; 150(3):606-19.

View in: PubMed

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