Epistasis, Genetic

"Epistasis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.

Descriptor ID	D004843
MeSH Number(s)	G05.308.207
Concept/Terms	Epistasis, Genetic Epistasis, Genetic Epistases, Genetic Gene-Gene Interactions, Epistatic Gene Gene Interactions, Epistatic Gene-Gene Interaction, Epistatic Epistatic Gene-Gene Interaction Epistatic Gene-Gene Interactions Gene Gene Interaction, Epistatic Interaction, Epistatic Gene-Gene Interactions, Epistatic Gene-Gene Non-Allelic Gene Interactions Gene Interaction, Non-Allelic Gene Interactions, Non-Allelic Interaction, Non-Allelic Gene Interactions, Non-Allelic Gene Non Allelic Gene Interactions Non-Allelic Gene Interaction Genetic Epistasis Genetic Epistases Genes, Epistatic Genes, Epistatic Epistatic Gene Epistatic Genes Gene, Epistatic Genes, Hypostatic Genes, Hypostatic Gene, Hypostatic Hypostatic Gene Hypostatic Genes Deviation, Epistatic Deviation, Epistatic Interaction Deviation Epistatic Deviation

Below are MeSH descriptors whose meaning is more general than "Epistasis, Genetic".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epistasis, Genetic [G05.308.207]

Below are MeSH descriptors whose meaning is more specific than "Epistasis, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epistasis, Genetic" by people in this website by year, and whether "Epistasis, Genetic" was a major or minor topic of these publications.

Bar chart showing 33 publications over 21 distinct years, with a maximum of 3 publications in 2012 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1998	1	0	1
1999	0	1	1
2000	0	1	1
2003	0	1	1
2005	0	2	2
2006	0	2	2
2007	0	1	1
2008	1	0	1
2009	0	2	2
2010	0	1	1
2011	0	1	1
2012	0	3	3
2013	0	3	3
2014	1	1	2
2016	0	2	2
2017	1	1	2
2018	2	0	2
2019	1	0	1
2020	1	1	2
2021	1	0	1

Below are the most recent publications written about "Epistasis, Genetic" by people in Profiles.

Dutta E, DeJesus MA, Ruecker N, Zaveri A, Koh EI, Sassetti CM, Schnappinger D, Ioerger TR. An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence. PLoS One. 2021; 16(10):e0257911.

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Klimova AN, Sandler SJ. An Epistasis Analysis of recA and recN in Escherichia coli K-12. Genetics. 2020 10; 216(2):381-393.

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Flynn JM, Rossouw A, Cote-Hammarlof P, Fragata I, Mavor D, Hollins C, Bank C, Bolon DN. Comprehensive fitness maps of Hsp90 show widespread environmental dependence. Elife. 2020 03 04; 9.

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Henes M, Kosovrasti K, Lockbaum GJ, Leidner F, Nachum GS, Nalivaika EA, Bolon DNA, Kurt Yilmaz N, Schiffer CA, Whitfield TW. Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance. Biochemistry. 2019 09 03; 58(35):3711-3726.

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Starr TN, Flynn JM, Mishra P, Bolon DNA, Thornton JW. Pervasive contingency and entrenchment in a billion years of Hsp90 evolution. Proc Natl Acad Sci U S A. 2018 04 24; 115(17):4453-4458.

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Canale AS, Cote-Hammarlof PA, Flynn JM, Bolon DN. Evolutionary mechanisms studied through protein fitness landscapes. Curr Opin Struct Biol. 2018 02; 48:141-148.

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DeJesus MA, Nambi S, Smith CM, Baker RE, Sassetti CM, Ioerger TR. Statistical analysis of genetic interactions in Tn-Seq data. Nucleic Acids Res. 2017 Jun 20; 45(11):e93.

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Flynn WF, Haldane A, Torbett BE, Levy RM. Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease. Mol Biol Evol. 2017 06 01; 34(6):1291-1306.

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Levy RM, Haldane A, Flynn WF. Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness. Curr Opin Struct Biol. 2017 04; 43:55-62.

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Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ, Soliman EZ, Chen LY, Smith JD, Van Wagoner DR, Rotter JI, Psaty BM, Xie Z, Hendricks AE, Ding J, Delgado GE, Verweij N, van der Harst P, Macfarlane PW, Ford I, Hofman A, Uitterlinden A, Heeringa J, Franco OH, Kors JA, Weiss S, Völzke H, Rose LM, Natarajan P, Kathiresan S, Kääb S, Gudnason V, Alonso A, Chung MK, Heckbert SR, Benjamin EJ, Liu Y, März W, Rienstra M, Jukema JW, Stricker BH, Dörr M, Albert CM, Ellinor PT. Gene-gene Interaction Analyses for Atrial Fibrillation. Sci Rep. 2016 11 08; 6:35371.

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