"Integrin alpha5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
| Descriptor ID |
D039482
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.500
|
| Concept/Terms |
Integrin alpha5- Integrin alpha5
- alpha5, Integrin
- alpha(5) Integrin
- alpha5 Integrin
- Integrin, alpha5
- VLA-5 alpha Chain
- VLA 5 alpha Chain
- alpha Chain, VLA-5
- CD49e Antigens
- Platelet Glycoprotein Ic
- Glycoprotein Ic, Platelet
- Ic, Platelet Glycoprotein
- Integrin alphaF
- alphaF, Integrin
- CD49e Antigen
- Antigen, CD49e
- Antigens, CD49e
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5".
This graph shows the total number of publications written about "Integrin alpha5" by people in this website by year, and whether "Integrin alpha5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha5" by people in Profiles.
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Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBP?-dependent induction of a5 integrin. Oncogene. 2014 May 08; 33(19):2441-53.
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Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7.
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Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47.