Eukaryotic Initiation Factor-4E
"Eukaryotic Initiation Factor-4E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.
Descriptor ID |
D039561
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MeSH Number(s) |
D12.776.157.725.750.374 D12.776.835.725.868.500.750
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Concept/Terms |
Eukaryotic Initiation Factor-4E- Eukaryotic Initiation Factor-4E
- Eukaryotic Initiation Factor 4E
- Factor-4E, Eukaryotic Initiation
- Initiation Factor-4E, Eukaryotic
- Peptide Initiation Factor EIF-4E
- Peptide Initiation Factor EIF 4E
- EIF4E
- Eukaryotic Peptide Initiation Factor-4E
- Eukaryotic Peptide Initiation Factor 4E
- CDC33 Gene Product
- EIF-4E
- EIF 4E
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Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4E".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4E".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4E" by people in this website by year, and whether "Eukaryotic Initiation Factor-4E" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2001 | 0 | 2 | 2 |
2002 | 0 | 2 | 2 |
2005 | 2 | 0 | 2 |
2006 | 2 | 0 | 2 |
2008 | 1 | 0 | 1 |
2009 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4E" by people in Profiles.
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Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J, Graelmann F, McCormick PN, Esser J, Tejera D, Nagano A, Wang J, Chelala C, Biederbick Y, Halle A, Salomoni P, Heneka MT, Capasso M. mTOR-dependent translation amplifies microglia priming in aging mice. J Clin Invest. 2021 01 04; 131(1).
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Cenik C, Chua HN, Singh G, Akef A, Snyder MP, Palazzo AF, Moore MJ, Roth FP. A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification. RNA. 2017 03; 23(3):270-283.
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Cao Q, Padmanabhan K, Richter JD. Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition. RNA. 2010 Jan; 16(1):221-7.
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Zhang L, Kimball SR, Jefferson LS, Shenberger JS. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radic Biol Med. 2009 Jun 01; 46(11):1500-9.
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Rosenwald IB, Koifman L, Savas L, Chen JJ, Woda BA, Kadin ME. Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma. Hum Pathol. 2008 Jun; 39(6):910-6.
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Shenberger JS, Zhang L, Hughlock MK, Ueda T, Watanabe-Fukunaga R, Fukunaga R. Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation. Int J Biochem Cell Biol. 2007; 39(10):1828-42.
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Cao Q, Kim JH, Richter JD. CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression. Nat Struct Mol Biol. 2006 Dec; 13(12):1128-34.
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Jung MY, Lorenz L, Richter JD. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. Mol Cell Biol. 2006 Jun; 26(11):4277-87.
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Barnard DC, Cao Q, Richter JD. Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus. Mol Cell Biol. 2005 Sep; 25(17):7605-15.
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Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature. 2005 Feb 03; 433(7025):477-80.