Eukaryotic Initiation Factor-4A
"Eukaryotic Initiation Factor-4A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of MRNA. The unwinding facilitates the binding of the 40S ribosomal subunit.
| Descriptor ID |
D039601
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| MeSH Number(s) |
D08.811.913.696.445.735.720.500 D12.776.835.725.868.500.500
|
| Concept/Terms |
Eukaryotic Initiation Factor-4A- Eukaryotic Initiation Factor-4A
- Eukaryotic Initiation Factor 4A
- Initiation Factor-4A, Eukaryotic
- EIF-4A
- Eukaryotic Peptide Initiation Factor-4A
- Eukaryotic Peptide Initiation Factor 4A
- Peptide Initiation Factor EIF-4A
- Peptide Initiation Factor EIF 4A
- Eukaryotic Initiation Factor EIF-4A
- Eukaryotic Initiation Factor EIF 4A
Eukaryotic Initiation Factor-4A2- Eukaryotic Initiation Factor-4A2
- Eukaryotic Initiation Factor 4A2
- Factor-4A2, Eukaryotic Initiation
- Initiation Factor-4A2, Eukaryotic
- EIF-4A2
Eukaryotic Initiation Factor-4A3- Eukaryotic Initiation Factor-4A3
- Eukaryotic Initiation Factor 4A3
- Factor-4A3, Eukaryotic Initiation
- Initiation Factor-4A3, Eukaryotic
- EIF-4A3
- EIF4AIII
- Eukaryotic Translation-Initiation Factor 4AIII
- Eukaryotic Translation Initiation Factor 4AIII
Eukaryotic Initiation Factor-4A1- Eukaryotic Initiation Factor-4A1
- Eukaryotic Initiation Factor 4A1
- Factor-4A1, Eukaryotic Initiation
- Initiation Factor-4A1, Eukaryotic
- EIF-4A1
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4A".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4A".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4A" by people in this website by year, and whether "Eukaryotic Initiation Factor-4A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4A" by people in Profiles.
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Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA, Pelletier J, R?tsch G, Wendel HG. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014 Sep 04; 513(7516):65-70.
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Rozovsky N, Butterworth AC, Moore MJ. Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. RNA. 2008 Oct; 14(10):2136-48.
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Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell. 2007 Jul 13; 130(1):179-91.
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Stroupe ME, Tange T?, Thomas DR, Moore MJ, Grigorieff N. The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21; 360(4):743-9.
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Shibuya T, Tange T?, Stroupe ME, Moore MJ. Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. RNA. 2006 Mar; 12(3):360-74.
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Tange T?, Shibuya T, Jurica MS, Moore MJ. Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA. 2005 Dec; 11(12):1869-83.
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Zhao R, Shen J, Green MR, MacMorris M, Blumenthal T. Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure. 2004 Aug; 12(8):1373-81.
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Shibuya T, Tange T?, Sonenberg N, Moore MJ. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol. 2004 Apr; 11(4):346-51.