 Protein Tyrosine Phosphatase, Non-Receptor Type 6
"Protein Tyrosine Phosphatase, Non-Receptor Type 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic cells. It plays a role in signal transduction by dephosphorylating signaling proteins that are activated or inactivated by PROTEIN-TYROSINE KINASES.
| Descriptor ID |
D053824
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| MeSH Number(s) |
D08.811.277.352.650.775.300.600 D08.811.277.352.650.775.700.200 D12.644.360.585.600 D12.644.360.800.200 D12.776.476.564.600 D12.776.476.800.200
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| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 6- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatase, Non Receptor Type 6
- Hematopoietic Cell Phosphatase
- Cell Phosphatase, Hematopoietic
- Phosphatase, Hematopoietic Cell
- Hematopoietic Cell-Specific Tyrosine Phosphatase SHP-1
- Hematopoietic Cell Specific Tyrosine Phosphatase SHP 1
- Protein Tyrosine Phosphatase 1C
- Protein Tyrosine Phosphatase, Nonreceptor Type 6
- SHP-1 Protein-Tyrosine Phosphatase
- Phosphatase, SHP-1 Protein-Tyrosine
- Protein-Tyrosine Phosphatase, SHP-1
- SHP 1 Protein Tyrosine Phosphatase
- SHP-1 Tyrosine Phosphatase
- Phosphatase, SHP-1 Tyrosine
- SHP 1 Tyrosine Phosphatase
- Tyrosine Phosphatase, SHP-1
- SHP1 Phosphatase
- Phosphatase, SHP1
- SHP1 Protein Tyrosine Phosphatase
- Haematopoietic Cell Phosphatase
- Cell Phosphatase, Haematopoietic
- Phosphatase, Haematopoietic Cell
- SHP-1 Phosphatase
- Phosphatase, SHP-1
- SHP 1 Phosphatase
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Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.300.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.700.200]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.585.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.644.360.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.800.200]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.564.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.800.200]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 6" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1994 | 0 | 1 | 1 | | 1997 | 0 | 6 | 6 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2008 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in Profiles.
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Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti TD. RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3. Nature. 2013 Jun 13; 498(7453):224-7.
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Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15028-33.
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Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med. 2006 May; 12(5):549-56.
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Lyons BL, Smith RS, Hurd RE, Hawes NL, Burzenski LM, Nusinowitz S, Hasham MG, Chang B, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1201-9.
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Park IK, Shultz LD, Letterio JJ, Gorham JD. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005 Nov 1; 175(9):5666-74.
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Huang Z, Coleman JM, Su Y, Mann M, Ryan J, Shultz LD, Huang H. SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner. Cytokine. 2005 Feb 7; 29(3):118-24.
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Lyons BL, Lynes MA, Burzenski L, Joliat MJ, Hadjout N, Shultz LD. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice. Exp Hematol. 2003 Mar; 31(3):234-43.
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Joliat MJ, Lang PA, Lyons BL, Burzenski L, Lynes MA, Yi T, Sundberg JP, Shultz LD. Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice. J Autoimmun. 2002 Mar; 18(2):105-17.
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Christianson SW, Greiner DL, Deluca D, Leif J, Phillips NE, Hayes SM, Hayashi S, Joliat MJ, Lyons BL, Shultz LD. T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7. J Autoimmun. 2002 Mar; 18(2):119-30.
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Mishra AK, Zhang A, Niu T, Yang J, Liang X, Zhao ZJ, Zhou GW. Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1. J Cell Biochem. 2002; 84(4):840-6.
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