"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Descriptor ID |
D008247
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MeSH Number(s) |
A11.284.430.214.190.875.190.550
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 2 | 3 |
1999 | 0 | 1 | 1 |
2000 | 3 | 1 | 4 |
2001 | 1 | 1 | 2 |
2002 | 0 | 1 | 1 |
2003 | 1 | 1 | 2 |
2004 | 1 | 1 | 2 |
2005 | 1 | 1 | 2 |
2006 | 1 | 2 | 3 |
2007 | 1 | 1 | 2 |
2008 | 4 | 3 | 7 |
2009 | 0 | 3 | 3 |
2010 | 2 | 2 | 4 |
2011 | 4 | 3 | 7 |
2012 | 1 | 5 | 6 |
2013 | 2 | 2 | 4 |
2014 | 0 | 7 | 7 |
2015 | 3 | 2 | 5 |
2016 | 1 | 2 | 3 |
2017 | 2 | 2 | 4 |
2018 | 0 | 4 | 4 |
2019 | 2 | 2 | 4 |
2020 | 3 | 2 | 5 |
2021 | 0 | 3 | 3 |
2022 | 1 | 3 | 4 |
2023 | 0 | 5 | 5 |
2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Tse-Kang SY, Pukkila-Worley R. Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity. Cell Rep. 2024 Sep 24; 43(9):114674.
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Tse-Kang SY, Wani KA, Peterson ND, Page A, Humphries F, Pukkila-Worley R. Intestinal immunity in C.?elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles. Immunity. 2024 Oct 08; 57(10):2280-2295.e6.
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Gutierrez-Ruiz OL, Johnson KM, Krueger EW, Nooren RE, Cruz-Reyes N, Heppelmann CJ, Hogenson TL, Fernandez-Zapico ME, McNiven MA, Razidlo GL. Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. Cell Rep. 2023 09 26; 42(9):113042.
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Kapadia A, Theil S, Opitz S, Villacampa N, Beckert H, Schoch S, Heneka MT, Kumar S, Walter J. Phosphorylation-state dependent intraneuronal sorting of A? differentially impairs autophagy and the endo-lysosomal system. Autophagy. 2024 01; 20(1):166-187.
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Doxsey DD, Tettoni SD, Egri SB, Shen K. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells. J Biol Chem. 2023 07; 299(7):104880.
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Rowland LA, Guilherme A, Henriques F, DiMarzio C, Munroe S, Wetoska N, Kelly M, Reddig K, Hendricks G, Pan M, Han X, Ilkayeva OR, Newgard CB, Czech MP. De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics. Nat Commun. 2023 03 13; 14(1):1362.
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Odongo L, Zadrozny KK, Diehl WE, Luban J, White JM, Ganser-Pornillos BK, Tamm LK, Pornillos O. Purification and structure of luminal domain C of human Niemann-Pick C1 protein. Acta Crystallogr F Struct Biol Commun. 2023 Feb 01; 79(Pt 2):45-50.
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Doxsey DD, Shen K. Purification and biochemical characterization of the Rag GTPase heterodimer. Methods Enzymol. 2022; 675:131-158.
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Bell CJ, Gupta N, Tremblay KD, Mager J. Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 08; 89(8):337-350.
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Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022 05 19; 82(10):1836-1849.e5.