CDC2 Protein Kinase

"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.

Descriptor ID	D016203
MeSH Number(s)	D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
Concept/Terms	CDC2 Protein Kinase CDC2 Protein Kinase Protein Kinase, CDC2 Cdk1 Protein Kinase Protein Kinase, Cdk1 cdk1 Kinase cdc2+ Protein Cyclin-Dependent Kinase 1 Cyclin Dependent Kinase 1 p34cdc2 Protein p34cdc2 Protein Protein p34cdc2 p34cdc2, Protein Histone Kinase p34(cdc2)

Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.500.250]
Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.984.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
CDC2 Protein Kinase [D12.644.360.250.067.249]
Maturation-Promoting Factor [D12.644.360.250.580]
CDC2 Protein Kinase [D12.644.360.250.580.500]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
CDC2 Protein Kinase [D12.776.167.200.067.249]
Maturation-Promoting Factor [D12.776.167.200.580]
CDC2 Protein Kinase [D12.776.167.200.580.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
CDC2 Protein Kinase [D12.776.476.250.067.249]
Maturation-Promoting Factor [D12.776.476.250.580]
CDC2 Protein Kinase [D12.776.476.250.580.500]
Phosphoproteins [D12.776.744]
CDC2 Protein Kinase [D12.776.744.360]

Below are MeSH descriptors whose meaning is related to "CDC2 Protein Kinase".

Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.

Bar chart showing 33 publications over 20 distinct years, with a maximum of 3 publications in 2002 and 2007 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	1	2
1999	0	2	2
2000	1	0	1
2001	0	1	1
2002	1	2	3
2005	0	2	2
2006	2	0	2
2007	2	1	3
2008	0	1	1
2009	1	1	2
2010	1	0	1
2012	0	3	3
2014	1	1	2
2015	2	0	2
2016	0	1	1
2017	0	1	1
2019	1	0	1
2020	0	1	1
2021	1	0	1
2026	0	1	1

Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.

Lee JS, Bui QT, Jo M, Morgan JS, Nasa I, Kettenbach AN, Shaw LM. Interaction of IRS2 with PLK1 protects cells from mitotic stress. Cell Death Dis. 2026 Apr 08; 17(1).

View in: PubMed
Huang Y, Fan Y, Zhao Z, Zhang X, Tucker K, Staley A, Suo H, Sun W, Shen X, Deng B, Pierce SR, West L, Yin Y, Emanuele MJ, Zhou C, Bae-Jump V. Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer. Int J Mol Sci. 2023 Aug 03; 24(15).

View in: PubMed
Ram?rez-Moya J, Miliotis C, Baker AR, Gregory RI, Slack FJ, Santisteban P. An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Mol Cancer. 2021 09 08; 20(1):115.

View in: PubMed
Castellani CM, Torres-Ocampo AP, Breffke J, White AB, Chambers JJ, Stratton MM, Maresca TJ. Live-cell FLIM-FRET using a commercially available system. Methods Cell Biol. 2020; 158:63-89.

View in: PubMed
Afonso O, Castellani CM, Cheeseman LP, Ferreira JG, Orr B, Ferreira LT, Chambers JJ, Morais-de-S? E, Maresca TJ, Maiato H. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife. 2019 08 19; 8.

View in: PubMed
Liu X, Gao Y, Ye H, Gerrin S, Ma F, Wu Y, Zhang T, Russo J, Cai C, Yuan X, Liu J, Chen S, Balk SP. Positive feedback loop mediated by protein phosphatase 1a mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer. Nucleic Acids Res. 2017 04 20; 45(7):3738-3751.

View in: PubMed
Fan X, Zhou Y, Chen JJ. Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene. Carcinogenesis. 2016 08; 37(8):799-809.

View in: PubMed
Van Oudenhove JJ, Grandy RA, Ghule PN, Del Rio R, Lian JB, Stein JL, Zaidi SK, Stein GS. Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause. Stem Cells. 2016 07; 34(7):1765-75.

View in: PubMed
Benanti JA. Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity. Curr Genet. 2016 May; 62(2):271-6.

View in: PubMed
Arsenault HE, Roy J, Mapa CE, Cyert MS, Benanti JA. Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation. Mol Biol Cell. 2015 Oct 15; 26(20):3570-7.

View in: PubMed

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