NADH Dehydrogenase

"NADH Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.

Descriptor ID	D009245
MeSH Number(s)	D08.811.682.608.504.500 D12.776.157.427.374.375.863.500 D12.776.331.887 D12.776.556.579.374.375.140.500
Concept/Terms	NADH Dehydrogenase NADH Dehydrogenase Dehydrogenase, NADH NADH Cytochrome c Oxidoreductase Diaphorase (NADH Dehydrogenase) NADH (Acceptor) Oxidoreductase NADH Cytochrome c Reductase

Below are MeSH descriptors whose meaning is more general than "NADH Dehydrogenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
NADH, NADPH Oxidoreductases [D08.811.682.608]
Electron Transport Complex I [D08.811.682.608.504]
NADH Dehydrogenase [D08.811.682.608.504.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Iron-Binding Proteins [D12.776.157.427]
Nonheme Iron Proteins [D12.776.157.427.374]
Iron-Sulfur Proteins [D12.776.157.427.374.375]
Electron Transport Complex I [D12.776.157.427.374.375.863]
NADH Dehydrogenase [D12.776.157.427.374.375.863.500]
Flavoproteins [D12.776.331]
NADH Dehydrogenase [D12.776.331.887]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Iron-Sulfur Proteins [D12.776.556.579.374.375]
Electron Transport Complex I [D12.776.556.579.374.375.140]
NADH Dehydrogenase [D12.776.556.579.374.375.140.500]

Below are MeSH descriptors whose meaning is more specific than "NADH Dehydrogenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NADH Dehydrogenase" by people in this website by year, and whether "NADH Dehydrogenase" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2004 and 2006 and 2012 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2006	1	0	1
2012	0	1	1
2021	1	0	1

Below are the most recent publications written about "NADH Dehydrogenase" by people in Profiles.

Zhang WZ, Hoffman KL, Schiffer KT, Oromendia C, Rice MC, Barjaktarevic I, Peters SP, Putcha N, Bowler RP, Wells JM, Couper DJ, Labaki WW, Curtis JL, Han MK, Paine R, Woodruff PG, Criner GJ, Hansel NN, Diaz I, Ballman KV, Nakahira K, Choi ME, Martinez FJ, Choi AMK, Cloonan SM. Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Respir Res. 2021 Apr 26; 22(1):126.

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Singh K, Singh IN, Diggins E, Connors SL, Karim MA, Lee D, Zimmerman AW, Frye RE. Developmental regression and mitochondrial function in children with autism. Ann Clin Transl Neurol. 2020 05; 7(5):683-694.

View in: PubMed
Oruganty-Das A, Ng T, Udagawa T, Goh EL, Richter JD. Translational control of mitochondrial energy production mediates neuron morphogenesis. Cell Metab. 2012 Dec 05; 16(6):789-800.

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Seo BB, Nakamaru-Ogiso E, Flotte TR, Matsuno-Yagi A, Yagi T. In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease. J Biol Chem. 2006 May 19; 281(20):14250-5.

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Mamelak AJ, Kowalski J, Murphy K, Yadava N, Zahurak M, Kouba DJ, Howell BG, Tzu J, Cummins DL, Li?geois NJ, Berg K, Sauder DN. Downregulation of NDUFA1 and other oxidative phosphorylation-related genes is a consistent feature of basal cell carcinoma. Exp Dermatol. 2005 May; 14(5):336-48.

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Seo BB, Nakamaru-Ogiso E, Cruz P, Flotte TR, Yagi T, Matsuno-Yagi A. Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: a potential therapy for complex I deficiencies. Hum Gene Ther. 2004 Sep; 15(9):887-95.

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Ricci JE, Mu?oz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86.

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Yadava N, Potluri P, Smith EN, Bisevac A, Scheffler IE. Species-specific and mutant MWFE proteins. Their effect on the assembly of a functional mammalian mitochondrial complex I. J Biol Chem. 2002 Jun 14; 277(24):21221-30.

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Scheffler IE, Yadava N. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J Bioenerg Biomembr. 2001 Jun; 33(3):243-50.

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