"Cathepsin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
- Cathepsin C
- Dipeptidyl Peptidase I
- Dipeptidyl Transferase
- Dipeptidyl Aminopeptidase I
Below are MeSH descriptors whose meaning is more general than "Cathepsin C".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin C".
This graph shows the total number of publications written about "Cathepsin C" by people in this website by year, and whether "Cathepsin C" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cathepsin C" by people in Profiles.
Kono H, Orlowski GM, Patel Z, Rock KL. The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol. 2012 Oct 01; 189(7):3734-40.
Hamilton G, Colbert JD, Schuettelkopf AW, Watts C. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J. 2008 Feb 06; 27(3):499-508.