 Cyclooxygenase 2
"Cyclooxygenase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
| Descriptor ID |
D051546
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| MeSH Number(s) |
D08.811.600.720.750
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| Concept/Terms |
Cyclooxygenase 2- Cyclooxygenase 2
- Cyclo-Oxygenase II
- Cyclo Oxygenase II
- PTGS2
- PGHS-2
- Prostaglandin H Synthase-2
- Prostaglandin H Synthase 2
- COX-2 Prostaglandin Synthase
- COX 2 Prostaglandin Synthase
- Prostaglandin Synthase, COX-2
- Synthase, COX-2 Prostaglandin
- Cyclooxygenase-2
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Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase 2".
Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase 2".
This graph shows the total number of publications written about "Cyclooxygenase 2" by people in this website by year, and whether "Cyclooxygenase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 4 | 4 | | 2005 | 1 | 5 | 6 | | 2006 | 1 | 3 | 4 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 2 | 3 | | 2010 | 3 | 3 | 6 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclooxygenase 2" by people in Profiles.
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Wu X, Song M, Rakariyatham K, Zheng J, Wang M, Xu F, Gao Z, Xiao H. Inhibitory Effects of 4'-Demethylnobiletin, a Metabolite of Nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Induced Inflammation in Mouse Ears. J Agric Food Chem. 2015 Dec 30; 63(51):10921-7.
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Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma'ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19; 39(3):599-610.
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Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013 Aug 16; 341(6147):789-92.
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O'Connor M, Kellett A, McCann M, Rosair G, McNamara M, Howe O, Creaven BS, McClean S, Kia AF, O'Shea D, Devereux M. Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines. J Med Chem. 2012 Mar 8; 55(5):1957-68.
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Yang CS, Lopez CG, Rana TM. Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells. 2011 Oct; 29(10):1528-36.
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Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M, Kleschyov AL, Daiber A, Keaney JF, Wegener G, Lackner K, Münzel T, Viollet B, Schulz E. a1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):560-6.
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Fleisher-Berkovich S, Filipovich-Rimon T, Ben-Shmuel S, Hülsmann C, Kummer MP, Heneka MT. Distinct modulation of microglial amyloid ß phagocytosis and migration by neuropeptides (i). J Neuroinflammation. 2010; 7:61.
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Lai CS, Tsai ML, Cheng AC, Li S, Lo CY, Wang Y, Xiao H, Ho CT, Wang YJ, Pan MH. Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mol Nutr Food Res. 2011 Feb; 55(2):278-90.
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Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):919-47.
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Carothers AM, Davids JS, Damas BC, Bertagnolli MM. Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. Cancer Res. 2010 Jun 1; 70(11):4433-42.
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