Cyclooxygenase 2

"Cyclooxygenase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.

Descriptor ID	D051546
MeSH Number(s)	D08.811.600.720.750
Concept/Terms	Cyclooxygenase 2 Cyclooxygenase 2 Cyclo-Oxygenase II Cyclo Oxygenase II PTGS2 PGHS-2 Prostaglandin H Synthase-2 Prostaglandin H Synthase 2 COX-2 Prostaglandin Synthase COX 2 Prostaglandin Synthase Prostaglandin Synthase, COX-2 Synthase, COX-2 Prostaglandin Cyclooxygenase-2

Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Prostaglandin-Endoperoxide Synthases [D08.811.600.720]
Cyclooxygenase 2 [D08.811.600.720.750]

Below are MeSH descriptors whose meaning is related to "Cyclooxygenase 2".

Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclooxygenase 2" by people in this website by year, and whether "Cyclooxygenase 2" was a major or minor topic of these publications.

Bar chart showing 69 publications over 25 distinct years, with a maximum of 10 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	2	2
2001	0	1	1
2002	0	7	7
2003	0	2	2
2004	0	10	10
2005	1	4	5
2006	0	3	3
2007	0	1	1
2008	0	2	2
2009	2	1	3
2010	1	5	6
2011	1	0	1
2013	0	1	1
2014	1	0	1
2015	0	2	2
2016	0	4	4
2017	0	1	1
2018	1	3	4
2019	2	0	2
2020	0	2	2
2021	1	2	3
2022	0	1	1
2023	0	2	2
2026	0	2	2

Below are the most recent publications written about "Cyclooxygenase 2" by people in Profiles.

Abdelmoez AM, Jollet M, Yu X, Rizo-Roca D, Marica AA, Ortiz de Zevallos J, Dollet L, Borg ML, Bj?rnholm M, Checa A, Olsson T, Otten J, Zierath JR, Krook A, Schwartz TW, Chibalin AV, Pillon NJ. Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle. Diabetologia. 2026 Jun; 69(6):1643-1658.

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Sharma P, Sharma RD, Sarkar B, Panwar V, Das M, Singh LV, Jain N, Chaturvedi S, Mehra L, Rathee A, Sharma S, Foo S, Lee A, N PK, Das P, Viswanathan V, Kornfeld H, Howland SW, Babu S, Nandicoori VK, Singhal A, Kumar D. Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis. Elife. 2026 Feb 05; 13.

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Youn DH, Han SW, Kim JT, Choi H, Lee A, Kim N, Jung H, Hong EP, Park CH, Lee Y, Cho SM, Jeon JP. Oxiracetam alleviates anti-inflammatory activity and ameliorates cognitive impairment in the early phase of traumatic brain injury. Acta Neurochir (Wien). 2023 08; 165(8):2201-2210.

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Gong Z, Li Q, Shi J, Li P, Hua L, Shultz LD, Ren G. Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis. Sci Immunol. 2023 02 24; 8(80):eadd5204.

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Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH, Shultz LD, Ren G. Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment. Immunity. 2022 08 09; 55(8):1483-1500.e9.

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Youn DH, Tran NM, Kim BJ, Kim Y, Jeon JP, Yoo H. Shape effect of cerium oxide nanoparticles on mild traumatic brain injury. Sci Rep. 2021 07 30; 11(1):15571.

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Ker?nen S, Suutarinen S, Mallick R, Laakkonen JP, Guo D, Pawlikowska L, Jahromi BR, Rauramaa T, Yl?-Herttuala S, Marchuk D, Krings T, Koivisto T, Lawton M, Radovanovic I, Kim H, Faughnan ME, Fr?sen J. Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation. Acta Neurochir (Wien). 2021 09; 163(9):2503-2514.

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Guo S, Wu X, Zheng J, Smith SA, Dong P, Xiao H. Identification of 4'-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities. J Agric Food Chem. 2021 Apr 21; 69(15):4381-4391.

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Morgan A, Gaulden A, Altemus M, Williford K, Centanni S, Winder D, Patel S. Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior. Brain Behav Immun. 2020 10; 89:513-517.

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Chen H, Wang K, Xiao H, Hu Z, Zhao L. Structural Characterization and Pro-inflammatory Activity of a Thaumatin-Like Protein from Pulp Tissues of Litchi chinensis. J Agric Food Chem. 2020 Jun 10; 68(23):6439-6447.

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