Cyclooxygenase 2

"Cyclooxygenase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.

Descriptor ID	D051546
MeSH Number(s)	D08.811.600.720.750
Concept/Terms	Cyclooxygenase 2 Cyclooxygenase 2 Cyclo-Oxygenase II Cyclo Oxygenase II PTGS2 PGHS-2 Prostaglandin H Synthase-2 Prostaglandin H Synthase 2 COX-2 Prostaglandin Synthase COX 2 Prostaglandin Synthase Prostaglandin Synthase, COX-2 Synthase, COX-2 Prostaglandin Cyclooxygenase-2

Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Prostaglandin-Endoperoxide Synthases [D08.811.600.720]
Cyclooxygenase 2 [D08.811.600.720.750]

Below are MeSH descriptors whose meaning is related to "Cyclooxygenase 2".

Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclooxygenase 2" by people in this website by year, and whether "Cyclooxygenase 2" was a major or minor topic of these publications.

Bar chart showing 68 publications over 25 distinct years, with a maximum of 10 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	2	2
2001	0	1	1
2002	0	8	8
2003	0	2	2
2004	0	10	10
2005	1	4	5
2006	1	3	4
2007	0	1	1
2008	0	2	2
2009	2	2	4
2010	1	5	6
2011	1	0	1
2013	0	1	1
2014	1	0	1
2015	0	2	2
2016	0	3	3
2017	0	1	1
2018	1	3	4
2019	2	0	2
2020	0	2	2
2021	1	1	2
2022	0	1	1
2023	0	1	1
2025	0	1	1

Below are the most recent publications written about "Cyclooxygenase 2" by people in Profiles.

Han Y, Guo X, Thanuphol P, Ji R, Zhu Z, Wu Y, Du H, Xiao H. Gut Microbiota-Mediated Degradation of Food-Grade Lambda-Carrageenan by Bacteroides xylanisolvens and Its Role in Inflammation. J Agric Food Chem. 2025 Feb 19; 73(7):4288-4298.

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Gong Z, Li Q, Shi J, Li P, Hua L, Shultz LD, Ren G. Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis. Sci Immunol. 2023 02 24; 8(80):eadd5204.

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Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH, Shultz LD, Ren G. Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment. Immunity. 2022 08 09; 55(8):1483-1500.e9.

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Ker?nen S, Suutarinen S, Mallick R, Laakkonen JP, Guo D, Pawlikowska L, Jahromi BR, Rauramaa T, Yl?-Herttuala S, Marchuk D, Krings T, Koivisto T, Lawton M, Radovanovic I, Kim H, Faughnan ME, Fr?sen J. Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation. Acta Neurochir (Wien). 2021 09; 163(9):2503-2514.

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Guo S, Wu X, Zheng J, Smith SA, Dong P, Xiao H. Identification of 4'-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities. J Agric Food Chem. 2021 Apr 21; 69(15):4381-4391.

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Morgan A, Gaulden A, Altemus M, Williford K, Centanni S, Winder D, Patel S. Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior. Brain Behav Immun. 2020 10; 89:513-517.

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Chen H, Wang K, Xiao H, Hu Z, Zhao L. Structural Characterization and Pro-inflammatory Activity of a Thaumatin-Like Protein from Pulp Tissues of Litchi chinensis. J Agric Food Chem. 2020 Jun 10; 68(23):6439-6447.

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Banhos Danneskiold-Sams?e N, Sonne SB, Larsen JM, Hansen AN, Fj?re E, Isidor MS, Petersen S, Henningsen J, Severi I, Sartini L, Schober Y, Wolf J, Nockher WA, Wolfrum C, Cinti S, Sina C, Hansen JB, Madsen L, Brix S, Kristiansen K. Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice. Sci Rep. 2019 06 20; 9(1):8979.

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Walker ME, Matthan NR, Goldbaum A, Meng H, Lamon-Fava S, Lakshman S, Jang S, Molokin A, Solano-Aguilar G, Urban JF, Lichtenstein AH. Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig. J Nutr Biochem. 2019 08; 70:138-146.

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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Physalactone and 4?-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. J Nat Prod. 2019 03 22; 82(3):492-499.

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