tau Proteins

"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

Descriptor ID	D016875
MeSH Number(s)	D12.776.220.600.450.510 D12.776.631.560.510
Concept/Terms	tau Proteins tau Proteins Proteins, tau tau Protein Protein, tau

Below are MeSH descriptors whose meaning is more general than "tau Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Microtubule Proteins [D12.776.220.600]
Microtubule-Associated Proteins [D12.776.220.600.450]
tau Proteins [D12.776.220.600.450.510]
Nerve Tissue Proteins [D12.776.631]
Microtubule-Associated Proteins [D12.776.631.560]
tau Proteins [D12.776.631.560.510]

Below are MeSH descriptors whose meaning is related to "tau Proteins".

Below are MeSH descriptors whose meaning is more specific than "tau Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.

Bar chart showing 189 publications over 27 distinct years, with a maximum of 21 publications in 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2001	0	1	1
2002	1	1	2
2003	1	0	1
2004	3	1	4
2005	2	3	5
2006	3	2	5
2007	4	0	4
2008	2	0	2
2009	3	4	7
2010	3	3	6
2011	2	4	6
2012	2	1	3
2013	3	1	4
2014	1	3	4
2015	0	2	2
2016	3	1	4
2017	3	1	4
2018	2	6	8
2019	11	7	18
2020	7	14	21
2021	3	8	11
2022	2	19	21
2023	0	14	14
2024	10	6	16
2025	5	4	9
2026	4	2	6

Below are the most recent publications written about "tau Proteins" by people in Profiles.

Koops EA, Giudicessi A, Baena A, Martinez L, Bonillas-Felix N, Medrano R, Dutta J, Gonzalez I, Alvarez S, Aguillon D, Quiroz YT, Jacobs HIL. Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2026 Jun; 22(6):e71587.

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Jiang X, Hoang TD, Shaw LM, Jacobs DR, Nasrallah IM, Bryan RN, Yaffe K. Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study. Lancet. 2026 May 30; 407(10544):2208-2216.

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Timsina J, Jiang C, McCartney DL, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta Fuentes R, Yang C, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo Morales A, Hohman TJ, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, Pijnenburg YAL, van der Flier WM, S?nchez-Juan P, Rodriguez-Rodriguez E, Kleineidam L, Peters O, Schneider A, K???kali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, D?zel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, P?rez-Tur J, Bullido MJ, S?nchez-Valle R, ?lvarez V, Garc?a-Gonz?lez P, Mir P, Real LM, Pi?ol-Ripoll G, Garc?a-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, N?then MM, Lewczuk P, Kornhuber J, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka MM, Fr?lich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Deleuze JF, Dufouil C, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hannon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, L?wenmark M, Kilander L, Genius P, Rodr?guez B, Luckett ES, Navarro A, Cano A, Marqui? M, Blennow K, Zetterberg H, Lleo A, Boada M, Ruiz A, Lee VM, Van Deerlin VM, Deming Y, Johnson SC, Engelman CD, Pastor P, Alvarez I, Peskind ER, Heslegrave AJ, Saykin AJ, Nho K, Schindler SE, Morris JC, Holtzman DM, McDade E, Renton AE, Goate A, Ibanez L, Riemenschneider M, Albert MS, Laws SM, Porter T, O'Brien EK, Shaw LM, Tijms BM, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie CW, Sims R, Belloy M, Lambert JC, Vilor-Tejedor N, Fern?ndez MV, Li QS, Nagle MW, Marioni RE, Ramirez A, Bertram L, van der Lee SJ, Cruchaga C. GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy. Nat Commun. 2026 Apr 21; 17(1).

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Robinson TL, Montenegro GDC, Fu JF, Pintucci EN, Properzi MJ, Penney DL, Davis R, Sperling RA, Johnson KA, Amariglio RE, Rentz DM. Digital maze test reveals cognitive performance patterns associated with amyloid-? and tau. Neuropsychology. 2026 Jul; 40(5):465-475.

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Carbone E, Zingaropoli MA, Perrone F, Talarico G, Pasculli P, Minni A, Petrella C, Barbato C, Piscopo P. Profile of Tau-Associated Selected MicroRNAs in Hospitalized COVID-19 Patients: An Exploratory Single-Center Study. Cells. 2026 Mar 12; 15(6).

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Petersen KK, Mil?-Alom? M, Li Y, Du L, Xiong C, Tosun D, Saef B, Saad ZS, Du-Cuny L, Coomaraswamy J, Mordashova Y, Rubel CE, Meyers EA, Shaw LM, Dage JL, Ashton NJ, Zetterberg H, Ferber K, Triana-Baltzer G, Baratta M, Rosenbaugh EG, Cruchaga C, McDade E, Holtzman DM, Morris JC, Sabandal JM, Bateman RJ, Bannon AW, Potter WZ, Schindler SE. Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. Nat Med. 2026 Mar; 32(3):1085-1094.

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Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH. Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease. Alzheimers Dement. 2025 12; 21(12):e70983.

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Cousins KAQ, Korecka M, Wan Y, Vulaj A, Brown C, Tropea TF, Lee EB, Tosun D, Landau SM, Okonkwo OC, Mindt MR, Weiner MW, Irwin DJ, Wolk DA, Shaw LM. Comparison of plasma p-tau217/A?42, p-tau217, and A?42/A?40 biomarkers by race to detect Alzheimer's disease. Alzheimers Dement. 2025 Aug; 21(8):e70469.

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Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy. Nucleic Acids Res. 2025 Jun 20; 53(12).

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Mil?-Alom? M, Tosun D, Schindler SE, Hausle I, Petersen KK, Li Y, Dage JL, Du-Cuny L, Saad ZS, Saef B, Triana-Baltzer G, Raunig DL, Coomaraswamy J, Baratta M, Meyers EA, Mordashova Y, Rubel CE, Ferber K, Kolb H, Ashton NJ, Zetterberg H, Rosenbaugh EG, Sabandal M, Shaw LM, Bannon AW, Potter WZ. Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks. Ann Neurol. 2025 09; 98(3):508-523.

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