"Pancreatic Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
| Descriptor ID |
D010191
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| MeSH Number(s) |
D06.472.699.587.700 D12.644.400.600 D12.644.548.586.700 D12.776.631.650.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pancreatic Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Pancreatic Polypeptide".
This graph shows the total number of publications written about "Pancreatic Polypeptide" by people in this website by year, and whether "Pancreatic Polypeptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pancreatic Polypeptide" by people in Profiles.
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Stengel A, Goebel-Stengel M, Teuffel P, Hofmann T, Bu?e P, Kobelt P, Rose M, Klapp BF. Obese patients have higher circulating protein levels of dipeptidyl peptidase IV. Peptides. 2014 Nov; 61:75-82.
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Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 2012; 98(5):451-65.
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Huber KL, Olson KD, Hardy JA. Robust production of a peptide library using methodological synchronization. Protein Expr Purif. 2009 Oct; 67(2):139-47.
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Seymour NE, Spector SA, Andersen DK, Elm MS, Whitcomb DC. Overexpression of hepatic pancreatic polypeptide receptors in chronic pancreatitis. J Surg Res. 1998 Apr; 76(1):47-52.
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Brunicardi FC, Chaiken RL, Ryan AS, Seymour NE, Hoffmann JA, Lebovitz HE, Chance RE, Gingerich RL, Andersen DK, Elahi D. Pancreatic polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis. J Clin Endocrinol Metab. 1996 Oct; 81(10):3566-72.
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Seymour NE, Volpert AR, Andersen DK. Regulation of hepatic insulin receptors by pancreatic polypeptide in fasting and feeding. J Surg Res. 1996 Sep; 65(1):1-4.
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Seymour NE, Volpert AR, Lee EL, Andersen DK, Hernandez C. Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide. Am J Surg. 1995 Jan; 169(1):105-9; discussion 110.
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Krasinski SD, Wheeler MB, Kopin AS, Leiter AB. Pancreatic polypeptide and peptide YY gene expression. Ann N Y Acad Sci. 1990; 611:73-85.
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Goldstein JA, Kirwin JD, Seymour NE, Trachtenberg JE, Rademaker EA, Andersen DK. Reversal of in vitro hepatic insulin resistance in chronic pancreatitis by pancreatic polypeptide in the rat. Surgery. 1989 Dec; 106(6):1128-32; discussion 1132-3.
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Brunicardi FC, Druck P, Seymour NE, Sun YS, Gingerich RL, Elahi D, Andersen DK. Splanchnic neural regulation of pancreatic polypeptide release in the isolated perfused human pancreas. Am J Surg. 1989 Jan; 157(1):50-7.