Tetrahydrofolate Dehydrogenase
"Tetrahydrofolate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
| Descriptor ID |
D013762
|
| MeSH Number(s) |
D08.811.682.662.825
|
| Concept/Terms |
Tetrahydrofolate Dehydrogenase- Tetrahydrofolate Dehydrogenase
- Dehydrogenase, Tetrahydrofolate
- Folic Acid Reductase
- Acid Reductase, Folic
- Reductase, Folic Acid
- Dihydrofolate Dehydrogenase
- Dehydrogenase, Dihydrofolate
- Dihydrofolate Reductase
- Reductase, Dihydrofolate
|
Below are MeSH descriptors whose meaning is more general than "Tetrahydrofolate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Tetrahydrofolate Dehydrogenase".
This graph shows the total number of publications written about "Tetrahydrofolate Dehydrogenase" by people in this website by year, and whether "Tetrahydrofolate Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Tetrahydrofolate Dehydrogenase" by people in Profiles.
-
Leidner F, Kurt Yilmaz N, Schiffer CA. Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning. J Chem Inf Model. 2021 06 28; 61(6):2537-2541.
-
Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM. Ligand-promoted protein folding by biased kinetic partitioning. Nat Chem Biol. 2017 04; 13(4):369-371.
-
Serebrov V, Moore MJ. Single Molecule Approaches in RNA-Protein Interactions. Adv Exp Med Biol. 2016; 907:89-106.
-
Philip D, Buch A, Moorthy D, Scott TM, Parnell LD, Lai CQ, Ordov?s JM, Selhub J, Rosenberg IH, Tucker KL, Troen AM. Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. Am J Clin Nutr. 2015 Nov; 102(5):1279-88.
-
Arai M, Iwakura M, Matthews CR, Bilsel O. Microsecond subdomain folding in dihydrofolate reductase. J Mol Biol. 2011 Jul 08; 410(2):329-42.
-
Alam MT, de Souza DK, Vinayak S, Griffing SM, Poe AC, Duah NO, Ghansah A, Asamoa K, Slutsker L, Wilson MD, Barnwell JW, Udhayakumar V, Koram KA. Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana. J Infect Dis. 2011 Jan 15; 203(2):220-7.
-
Kairys V, Gilson MK, Lather V, Schiffer CA, Fernandes MX. Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis. Chem Biol Drug Des. 2009 Sep; 74(3):234-45.
-
Arai M, Kondrashkina E, Kayatekin C, Matthews CR, Iwakura M, Bilsel O. Microsecond hydrophobic collapse in the folding of Escherichia coli dihydrofolate reductase, an alpha/beta-type protein. J Mol Biol. 2007 Apr 20; 368(1):219-29.
-
Galli Marxer C, Kraft ML, Weber PK, Hutcheon ID, Boxer SG. Supported membrane composition analysis by secondary ion mass spectrometry with high lateral resolution. Biophys J. 2005 Apr; 88(4):2965-75.
-
Vanguri VK, Wang S, Godyna S, Ranganathan S, Liau G. Thrombospondin-1 binds to polyhistidine with high affinity and specificity. Biochem J. 2000 Apr 15; 347(Pt 2):469-73.