Tetrahydrofolate Dehydrogenase

"Tetrahydrofolate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.

Descriptor ID	D013762
MeSH Number(s)	D08.811.682.662.825
Concept/Terms	Tetrahydrofolate Dehydrogenase Tetrahydrofolate Dehydrogenase Dehydrogenase, Tetrahydrofolate Folic Acid Reductase Acid Reductase, Folic Reductase, Folic Acid Dihydrofolate Dehydrogenase Dehydrogenase, Dihydrofolate Dihydrofolate Reductase Reductase, Dihydrofolate

Below are MeSH descriptors whose meaning is more general than "Tetrahydrofolate Dehydrogenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxidoreductases Acting on CH-NH Group Donors [D08.811.682.662]
Tetrahydrofolate Dehydrogenase [D08.811.682.662.825]

Below are MeSH descriptors whose meaning is related to "Tetrahydrofolate Dehydrogenase".

Below are MeSH descriptors whose meaning is more specific than "Tetrahydrofolate Dehydrogenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tetrahydrofolate Dehydrogenase" by people in this website by year, and whether "Tetrahydrofolate Dehydrogenase" was a major or minor topic of these publications.

Bar chart showing 17 publications over 11 distinct years, with a maximum of 2 publications in 2000 and 2009 and 2017 and 2020 and 2021 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	2	2
2006	1	0	1
2009	1	1	2
2012	1	0	1
2016	0	1	1
2017	1	1	2
2020	1	1	2
2021	1	1	2
2022	0	2	2
2024	0	1	1

Below are the most recent publications written about "Tetrahydrofolate Dehydrogenase" by people in Profiles.

Carey-Ewend K, Popkin-Hall ZR, Simkin A, Muller M, Hennelly C, He W, Moser KA, Gaither C, Niar? K, Aghakanian F, Feleke S, Brhane BG, Phanzu F, Kashamuka MM, Aydemir O, Sutherland CJ, Ishengoma DS, Ali IM, Ngasala B, Kalonji A, Tshefu A, Parr JB, Bailey JA, Juliano JJ, Lin JT. Population genomics of Plasmodium ovale species in sub-Saharan Africa. Nat Commun. 2024 11 27; 15(1):10297.

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Dosoo DK, Bailey JA, Asante KP, Oppong FB, Niar? K, Opoku-Mensah J, Owusu-Agyei S, Greenwood B, Chandramohan D. The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana. PLoS One. 2022; 17(8):e0271489.

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Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ. Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. J Infect Dis. 2022 02 15; 225(4):696-704.

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Leidner F, Kurt Yilmaz N, Schiffer CA. Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning. J Chem Inf Model. 2021 06 28; 61(6):2537-2541.

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Lozovsky ER, Daniels RF, Heffernan GD, Jacobus DP, Hartl DL. Relevance of Higher-Order Epistasis in Drug Resistance. Mol Biol Evol. 2021 01 04; 38(1):142-151.

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Torrevillas BK, Garrison SM, McKeeken AJ, Patel D, Van Leuven JT, Dizon NI, Rivas KI, Hathaway NJ, Bailey JA, Waitumbi JN, Kifude CM, Oyieko J, Stewart VA, Luckhart S. Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya. Front Cell Infect Microbiol. 2020; 10:600112.

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Sitali L, Mwenda MC, Miller JM, Bridges DJ, Hawela MB, Hamainza B, Mudenda-Chilufya M, Chizema-Kawesha E, Daniels RF, Eisele TP, Nerland AH, Chipeta J, Lindtjorn B. Surveillance of molecular markers for antimalarial resistance in Zambia: Polymorphism of Pfkelch 13, Pfmdr1 and Pfdhfr/Pfdhps genes. Acta Trop. 2020 Dec; 212:105704.

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Ndiaye YD, Di?dhiou CK, Bei AK, Dieye B, Mbaye A, Mze NP, Daniels RF, Ndiaye IM, D?me AB, Gaye A, Sy M, Ndiaye T, Badiane AS, Ndiaye M, Premji Z, Wirth DF, Mboup S, Krogstad D, Volkman SK, Ahouidi AD, Ndiaye D. High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malar J. 2017 Apr 19; 16(1):153.

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Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM. Ligand-promoted protein folding by biased kinetic partitioning. Nat Chem Biol. 2017 04; 13(4):369-371.

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Serebrov V, Moore MJ. Single Molecule Approaches in RNA-Protein Interactions. Adv Exp Med Biol. 2016; 907:89-106.

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