Granzymes

"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.

Descriptor ID	D053804
MeSH Number(s)	D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
Concept/Terms	Granzymes Granzymes Granzyme Granzyme M Granzyme M Granzyme C Granzyme C Granzyme K Granzyme K Natural Killer Cell Granule Tryptase-2 Natural Killer Cell Granule Tryptase 2 NK-Tryptase-2 NK Tryptase 2 Granzyme-3 Granzyme 3 Granzyme A Granzyme A Cytotoxic T-Lymphocyte Proteinase 1 Cytotoxic T Lymphocyte Proteinase 1 Hanukah Factor Granzyme B Granzyme B Fragmentin 2 Cytotoxic T-Lymphocyte Associated 1 Protein Cytotoxic T Lymphocyte Associated 1 Protein Granzyme-Like Protein III Granzyme Like Protein III Cytotoxic Serine Protease B

Below are MeSH descriptors whose meaning is more general than "Granzymes".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Granzymes [D08.811.277.656.300.760.397]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Granzymes [D08.811.277.656.959.350.397]

Below are MeSH descriptors whose meaning is more specific than "Granzymes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2003	0	1	1
2009	0	2	2
2010	1	0	1
2011	0	1	1
2013	1	0	1
2016	1	1	2
2017	1	1	2
2018	0	2	2
2020	0	3	3
2021	0	1	1
2025	0	1	1

Below are the most recent publications written about "Granzymes" by people in Profiles.

Shinkawa T, Chang E, Rakib T, Cavallo K, Lai R, Behar SM. CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages. Cell Rep. 2025 Sep 23; 44(9):116184.

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Junqueira C, Polidoro RB, Castro G, Absalon S, Liang Z, Sen Santara S, Crespo ?, Pereira DB, Gazzinelli RT, Dvorin JD, Lieberman J. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357.

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Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 11 25; 183(5):1219-1233.e18.

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Nguyen A, Ramesh A, Kumar S, Nandi D, Brouillard A, Wells A, Pobezinsky L, Osborne B, Kulkarni AA. Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy. Sci Adv. 2020 10; 6(40).

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Pan S, Jeon T, Luther DC, Duan X, Rotello VM. Cytosolic Delivery of Functional Proteins In Vitro through Tunable Gigahertz Acoustics. ACS Appl Mater Interfaces. 2020 Apr 01; 12(13):15823-15829.

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Adams HC, Stevenaert F, Krejcik J, Van der Borght K, Smets T, Bald J, Abraham Y, Ceulemans H, Chiu C, Vanhoof G, Usmani SZ, Plesner T, Lonial S, Nijhof I, Lokhorst HM, Mutis T, van de Donk NWCJ, Sasser AK, Casneuf T. High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action. Cytometry A. 2019 03; 95(3):279-289.

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Hatfield SD, Daniels KA, O'Donnell CL, Waggoner SN, Welsh RM. Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity. Virology. 2018 06; 519:131-144.

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Silveira GF, Wowk PF, Cataneo AHD, Dos Santos PF, Delgobo M, Stimamiglio MA, Lo Sarzi M, Thomazelli APFS, Conchon-Costa I, Pavanelli WR, Antonelli LRV, B?fica A, Mansur DS, Dos Santos CND, Bordignon J. Human T Lymphocytes Are Permissive for Dengue Virus Replication. J Virol. 2018 05 15; 92(10).

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Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21).

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Lucinda N, Figueiredo MM, Pessoa NL, Santos BS, Lima GK, Freitas AM, Machado AM, Kroon EG, Antonelli LR, Campos MA. Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B. Virol J. 2017 02 21; 14(1):37.

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