Urokinase-Type Plasminogen Activator

"Urokinase-Type Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.

Descriptor ID	D014568
MeSH Number(s)	D08.811.277.656.300.760.910 D08.811.277.656.959.350.910 D12.776.124.125.662.884
Concept/Terms	Urokinase-Type Plasminogen Activator Urokinase-Type Plasminogen Activator Urokinase Type Plasminogen Activator Plasminogen Activator, Urokinase-Type U-Plasminogen Activator U Plasminogen Activator U-PA Urinary Plasminogen Activator Urokinase Renokinase Renokinase Abbokinase Abbokinase Kidney Plasminogen Activator Kidney Plasminogen Activator Single-Chain Urokinase-Type Plasminogen Activator Single-Chain Urokinase-Type Plasminogen Activator Single Chain Urokinase Type Plasminogen Activator

Below are MeSH descriptors whose meaning is more general than "Urokinase-Type Plasminogen Activator".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Urokinase-Type Plasminogen Activator [D08.811.277.656.300.760.910]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Urokinase-Type Plasminogen Activator [D08.811.277.656.959.350.910]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
Plasminogen Activators [D12.776.124.125.662]
Urokinase-Type Plasminogen Activator [D12.776.124.125.662.884]

Below are MeSH descriptors whose meaning is related to "Urokinase-Type Plasminogen Activator".

Below are MeSH descriptors whose meaning is more specific than "Urokinase-Type Plasminogen Activator".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Urokinase-Type Plasminogen Activator" by people in this website by year, and whether "Urokinase-Type Plasminogen Activator" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 1996 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	2	0	2
1997	1	0	1
2000	1	0	1
2003	1	0	1
2004	1	0	1
2010	0	2	2
2013	0	1	1

Below are the most recent publications written about "Urokinase-Type Plasminogen Activator" by people in Profiles.

Koenigs A, Hammerschmidt C, Jutras BL, Pogoryelov D, Barthel D, Skerka C, Kugelstadt D, Wallich R, Stevenson B, Zipfel PF, Kraiczy P. BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem. 2013 Aug 30; 288(35):25229-25243.

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Hawse WF, Champion MM, Joyce MV, Hellman LM, Hossain M, Ryan V, Pierce BG, Weng Z, Baker BM. Cutting edge: Evidence for a dynamically driven T cell signaling mechanism. J Immunol. 2012 Jun 15; 188(12):5819-23.

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Yoo AJ, Hakimelahi R, Rost NS, Schaefer PW, Hirsch JA, Gonz?lez RG, Rabinov JD. Diffusion weighted imaging reversibility in the brainstem following successful recanalization of acute basilar artery occlusion. J Neurointerv Surg. 2010 Sep; 2(3):195-7.

View in: PubMed
Goddeau RP, Caplan LR, Alhazzani AA. Intraparenchymal hemorrhage in a patient with osteogenesis imperfecta and plasminogen activator inhibitor-1 deficiency. Arch Neurol. 2010 Feb; 67(2):236-8.

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Kulcs?r Z, Marosfoi M, Berentei Z, Szikora I. Continuous thrombolysis and repeated thrombectomy with the Penumbra System in a child with hemorrhagic sinus thrombosis: technical note. Acta Neurochir (Wien). 2010 May; 152(5):911-6.

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Fritz V, No?l D, Bouquet C, Opolon P, Voide R, Apparailly F, Louis-Plence P, Bouffi C, Drissi H, Xie C, Perricaudet M, M?ller R, Schwarz E, Jorgensen C. Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumor. Stem Cells. 2008 Nov; 26(11):2981-90.

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Beaulieu LM, Whitley BR, Wiesner TF, Rehault SM, Palmieri D, Elkahloun AG, Church FC. Breast cancer and metabolic syndrome linked through the plasminogen activator inhibitor-1 cycle. Bioessays. 2007 Oct; 29(10):1029-38.

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Whitley BR, Beaulieu LM, Carter JC, Church FC. Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol Oncol. 2007 Feb; 104(2):470-9.

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Hall CL, Tsan R, Mugnai G, Mazar A, Radinsky R, Pettaway CA. Enhanced invasion of hormone refractory prostate cancer cells through hepatocyte growth factor (HGF) induction of urokinase-type plasminogen activator (u-PA). Prostate. 2004 May 01; 59(2):167-76.

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Gates J, Hartnell GG. When urokinase was gone: commentary on another year of thrombolysis without urokinase. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 1):1-5.

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