"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
| Descriptor ID |
D005341
|
| MeSH Number(s) |
D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
|
| Concept/Terms |
Fibrinolysin- Fibrinolysin
- Plasmin
- Protease F
- Glu-Plasmin
- Glu Plasmin
|
Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".
Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".
This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibrinolysin" by people in Profiles.
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Yang D, Yang H, Luiselli G, Ogagan C, Dai H, Chiu L, Carroll RS, Johnson MD. Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).
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Wu WC, Liu CH, Wang NK, Chen KJ, Chen TL, Hwang YS, Liao PJ, Li LM, Lai CC. Lens subluxation after plasmin and SF6 injections in rabbit eyes. PLoS One. 2014; 9(11):e112957.
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Wu WC, Liu CH, Chen CC, Wang NK, Chen KJ, Chen TL, Hwang YS, Li LM, Lai CC. Efficient vitreolysis by combining plasmin and sulfur hexafluoride injection in a preclinical study in rabbit eyes. Mol Vis. 2012; 18:2361-70.
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Wu WC, Chen CC, Liu CH, Wang NK, Chen KJ, Chen TL, Hwang YS, Li LM, Lai CC. Plasmin treatment accelerates vascular endothelial growth factor clearance from rabbit eyes. Invest Ophthalmol Vis Sci. 2011 Aug 03; 52(9):6162-7.
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Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):42-8.
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Li Yf, Spencer FA, Becker RC. Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor. J Thromb Thrombolysis. 2003 Feb; 15(1):19-23.
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Welling TH, Huber TS, Messina LM, Stanley JC. Tissue plasminogen activator increases canine endothelial cell proliferation rate through a plasmin-independent, receptor-mediated mechanism. J Surg Res. 1996 Nov; 66(1):36-42.
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Liu L, Freedman J, Hornstein A, Dewar L, Blajchman MA, Ofosu FA. Plasmin accelerates platelet-dependent prothrombinase formation without activating the platelets. Br J Haematol. 1996 Feb; 92(2):458-65.
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Loscalzo J, Pasche B, Ouimet H, Freedman JE. Platelets and plasminogen activation. Thromb Haemost. 1995 Jul; 74(1):291-3.
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Klempner MS, Noring R, Epstein MP, McCloud B, Hu R, Limentani SA, Rogers RA. Binding of human plasminogen and urokinase-type plasminogen activator to the Lyme disease spirochete, Borrelia burgdorferi. J Infect Dis. 1995 May; 171(5):1258-65.