DNA-Directed DNA Polymerase

"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.

Descriptor ID	D004259
MeSH Number(s)	D08.811.913.696.445.308.300
Concept/Terms	DNA-Directed DNA Polymerase DNA-Directed DNA Polymerase DNA Directed DNA Polymerase DNA Polymerase, DNA-Directed Polymerase, DNA-Directed DNA DNA-Dependent DNA Polymerases DNA Dependent DNA Polymerases DNA Polymerases, DNA-Dependent Polymerases, DNA-Dependent DNA DNA Polymerases Polymerases, DNA DNA Polymerase N3 DNA Polymerase N3 Polymerase N3, DNA

Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
DNA Nucleotidyltransferases [D08.811.913.696.445.308]
DNA-Directed DNA Polymerase [D08.811.913.696.445.308.300]

Below are MeSH descriptors whose meaning is related to "DNA-Directed DNA Polymerase".

Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.

Bar chart showing 12 publications over 11 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2005	0	1	1
2006	1	0	1
2007	1	0	1
2010	1	0	1
2011	1	1	2
2012	1	0	1
2019	1	0	1
2022	0	1	1
2023	1	0	1
2024	0	1	1

Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.

Zaino AM, Dash RC, James SJ, MacGilvary N, Crompton A, McPherson KS, Stanzione M, Korzhnev DM, Dyson NJ, Chatterjee N, Cantor SB, Hadden MK. Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction. Bioorg Med Chem. 2024 May 15; 106:117755.

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Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ. Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Nat Biotechnol. 2024 Jul; 42(7):1039-1045.

View in: PubMed
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch BA. Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife. 2022 02 18; 11.

View in: PubMed
Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Molecular basis of microhomology-mediated end-joining by purified full-length Pol?. Nat Commun. 2019 09 27; 10(1):4423.

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Feng G, Thumbi DK, de Jong J, Hodgson JJ, Arif BM, Doucet D, Krell PJ. Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutations. J Virol. 2012 Dec; 86(24):13576-88.

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Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF. RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions. J Virol. 2012 May; 86(10):5660-73.

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Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. A novel agent effective against Clostridium difficile infection. Antimicrob Agents Chemother. 2012 Mar; 56(3):1624-6.

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Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp. Science. 2011 Dec 23; 334(6063):1675-80.

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Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM. Novel role of base excision repair in mediating cisplatin cytotoxicity. J Biol Chem. 2011 Apr 22; 286(16):14564-74.

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Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Z?chner S. The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab. 2010 Dec 01; 12(6):675-82.

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