"Aromatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Descriptor ID |
D001141
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MeSH Number(s) |
D08.244.453.489.500 D08.244.453.915.099 D08.811.682.690.708.170.447.500 D08.811.682.690.708.170.915.099 D12.776.422.220.453.489.500 D12.776.422.220.453.915.099
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Concept/Terms |
Aromatase- Aromatase
- Estrogen Synthetase
- Estrogen Synthase
- Cytochrome P450 19
- CYP19 Protein
- Protein, CYP19
- Cytochrome P-450(AROM)
- CYP 19
- Cytochrome P-450 CYP19
- Cytochrome P 450 CYP19
- P450AROM
- Androstenedione Aromatase
- Aromatase, Androstenedione
- CYP19
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Below are MeSH descriptors whose meaning is more general than "Aromatase".
Below are MeSH descriptors whose meaning is more specific than "Aromatase".
This graph shows the total number of publications written about "Aromatase" by people in this website by year, and whether "Aromatase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2007 | 0 | 1 | 1 |
2009 | 0 | 2 | 2 |
2010 | 3 | 1 | 4 |
2011 | 1 | 2 | 3 |
2012 | 1 | 0 | 1 |
2017 | 2 | 0 | 2 |
2018 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aromatase" by people in Profiles.
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Singh Y, Jaswal S, Singh S, Verma SK, Thareja S. Dual aromatase-steroid sulfatase inhibitors (DASI's) for the treatment of breast cancer: a structure guided ligand based designing approach. J Biomol Struct Dyn. 2023 12; 41(20):10604-10626.
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Banjare L, Singh Y, Verma SK, Singh AK, Kumar P, Kumar S, Jain AK, Thareja S. Multifaceted 3D-QSAR analysis for the identification of pharmacophoric features of biphenyl analogues as aromatase inhibitors. J Biomol Struct Dyn. 2023 03; 41(4):1322-1341.
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Zhang M, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis and Structure-Activity Relationships of Tetrahydro-?-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents. Anticancer Res. 2018 Aug; 38(8):4425-4433.
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Prior AM, Yu X, Park EJ, Kondratyuk TP, Lin Y, Pezzuto JM, Sun D. Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. Bioorg Med Chem Lett. 2017 12 15; 27(24):5393-5399.
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Pederson T. Angela Hartley Brodie, 1934-2017: Assailant of Aromatase. FASEB J. 2017 10; 31(10):4205-4206.
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Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorg Med Chem. 2012 Apr 01; 20(7):2427-34.
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Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorg Med Chem. 2012 Jan 01; 20(1):510-20.
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Shen L, Park EJ, Kondratyuk TP, Guendisch D, Marler L, Pezzuto JM, Wright AD, Sun D. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011 Nov 01; 19(21):6182-95.
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Luqman S, Meena A, Marler LE, Kondratyuk TP, Pezzuto JM. Suppression of tumor necrosis factor-a-induced nuclear factor ?B activation and aromatase activity by capsaicin and its analog capsazepine. J Med Food. 2011 Nov; 14(11):1344-51.
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Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 08; 53(13):5033-43.